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Literature summary extracted from

  • Blaby, I.K.; Majumder, M.; Chatterjee, K.; Jana, S.; Grosjean, H.; de Crecy-Lagard, V.; Gupta, R.
    Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii (2011), RNA, 17, 1367-1380.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.B4 additional information Haloferax volcanii pseudouridylation of Haloferax volcanii 23S rRNA is Cbf5-mediated ?
-
 ?
5.4.99.B4 additional information Haloferax volcanii DSM 3757 pseudouridylation of Haloferax volcanii 23S rRNA is Cbf5-mediated ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.B4 Haloferax volcanii
-
-
-
5.4.99.B4 Haloferax volcanii D4GTP8
-
-
5.4.99.B4 Haloferax volcanii DSM 3757 D4GTP8
-
-
5.4.99.B4 Haloferax volcanii H26
-
-
-
5.4.99.B25 Haloferax volcanii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.B4 23S rRNA uridine Cbf5 is needed for pseudouridylation of the large subunit rRNA residues Haloferax volcanii 23S rRNA pseudouridine
-
 ?
5.4.99.B4 23S rRNA uridine Cbf5 is needed for pseudouridylation of the large subunit rRNA residues Haloferax volcanii H26 23S rRNA pseudouridine
-
 ?
5.4.99.B4 additional information pseudouridylation of Haloferax volcanii 23S rRNA is Cbf5-mediated Haloferax volcanii ?
-
 ?
5.4.99.B4 additional information pseudouridylation of Haloferax volcanii 23S rRNA is Cbf5-mediated Haloferax volcanii DSM 3757 ?
-
 ?
5.4.99.B25 tRNA uridine54
-
 Haloferax volcanii tRNA pseudouridine54
-
 ?
5.4.99.B25 tRNA uridine54
-
 Haloferax volcanii H26 tRNA pseudouridine54
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.B4 Cbf5
-
 Haloferax volcanii
5.4.99.B4 Cbf5 homolog
-
 Haloferax volcanii
5.4.99.B4 HVO 2493
-
 Haloferax volcanii
5.4.99.B4 pseudouridine synthase
-
 Haloferax volcanii
5.4.99.B4 PSI synthase
-
 Haloferax volcanii
5.4.99.B25 Pus10
-
 Haloferax volcanii
5.4.99.B25 tRNA psi54 synthase
-
 Haloferax volcanii

General Information

EC Number General Information Comment Organism
5.4.99.B4 malfunction deletion of cbf5 does not lead to any obvious phenotype, the Cbf5-deleted strain of Haloferax volcanii completely lacks pseudouridine at positions 1940, 1942, 2605, and 2591 of its 23S rRNA, and contains reduced steady-state levels of some box H/ACA RNAs Haloferax volcanii
5.4.99.B4 malfunction cbf5 deletion reduces the amounts of guide box H/ACA RNAs Haloferax volcanii
5.4.99.B4 physiological function the Cbf5 homolog (HVO 2493) is not essential in Haloferax volcanii. Cbf5 is not needed for most of the tRNA pseudouridine residues of Haloferax volcanii Haloferax volcanii
5.4.99.B4 physiological function the enzyme Cbf5 is responsible for making pseudouridine at multiple positions of the large subunit of rRNA Haloferax volcanii