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Literature summary extracted from

  • Polydorides, S.; Amara, N.; Aubard, C.; Plateau, P.; Simonson, T.; Archontis, G.
    Computational protein design with a generalized born solvent model: application to asparaginyl-tRNA synthetase (2011), Proteins, 79, 3448-3468.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.22 Thermus thermophilus
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-
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6.3.5.6 Thermus thermophilus
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-
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Subunits

EC Number Subunits Comment Organism
6.3.5.6 homodimer
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 Thermus thermophilus

Synonyms

EC Number Synonyms Comment Organism
6.1.1.22 AsnRS
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 Thermus thermophilus
6.1.1.22 Asparaginyl-tRNA synthetase
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 Thermus thermophilus
6.3.5.6 AsnRS
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 Thermus thermophilus
6.3.5.6 Asparaginyl-tRNA synthetase
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 Thermus thermophilus

Expression

EC Number Organism Comment Expression
6.1.1.22 Thermus thermophilus engineering of aspartyladenylate, AspAMP, specificity into asparaginyl-tRNA synthetase, AsnRS, whose substrate is asparaginyl-adenylate by CPD method, that uses a polar-hydrogen energy function for protein interactions and a coulomb/accessible surface area model for solvent effects, method development, overview. Application of an all-atom energy for protein interactions and a residue-pairwise generalized Born model for solvent effects, overview. The conformations and interactions are well maintained in molecular dynamics simulations and the sequences have an inverted specificity, favoring AspAMP over AsnAMP additional information