Literature summary extracted from

Bourquin, F.; Capitani, G.; Gruetter, M.G.
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism (2011), Protein Sci., 20, 1492-1508.

Protein Variants

EC Number	Protein Variants	Comment	Organism
4.1.2.27	H129A	the mutation drastically impairs enzyme activity	Saccharomyces cerevisiae
4.1.2.27	H129A	the mutation drastically impairs enzyme activity	Symbiobacterium thermophilum
4.1.2.27	Y105F	inactive	Saccharomyces cerevisiae
4.1.2.27	Y174F	the mutant is partially active	Saccharomyces cerevisiae

Inhibitors

EC Number	Inhibitors	Comment	Organism
4.1.2.27	1-deoxydihydrosphingosine 1-phosphonate	-	Homo sapiens
4.1.2.27	1-deoxydihydrosphingosine 1-phosphonate	-	Myxococcus xanthus
4.1.2.27	1-deoxydihydrosphingosine 1-phosphonate	-	Saccharomyces cerevisiae
4.1.2.27	1-deoxydihydrosphingosine 1-phosphonate	-	Symbiobacterium thermophilum
4.1.2.27	2-acetyl-4-tetrahydroxybutyl-imidazole	-	Homo sapiens
4.1.2.27	2-acetyl-4-tetrahydroxybutyl-imidazole	-	Myxococcus xanthus
4.1.2.27	2-acetyl-4-tetrahydroxybutyl-imidazole	-	Saccharomyces cerevisiae
4.1.2.27	2-acetyl-4-tetrahydroxybutyl-imidazole	-	Symbiobacterium thermophilum
4.1.2.27	2-vinyldihydro-sphingosine 1-phosphate	-	Homo sapiens
4.1.2.27	2-vinyldihydro-sphingosine 1-phosphate	-	Myxococcus xanthus
4.1.2.27	2-vinyldihydro-sphingosine 1-phosphate	-	Saccharomyces cerevisiae
4.1.2.27	2-vinyldihydro-sphingosine 1-phosphate	-	Symbiobacterium thermophilum
4.1.2.27	Ca2+	-	Homo sapiens
4.1.2.27	Ca2+	-	Myxococcus xanthus
4.1.2.27	Ca2+	-	Saccharomyces cerevisiae
4.1.2.27	Ca2+	-	Symbiobacterium thermophilum
4.1.2.27	FTY720	also called fingolimod	Homo sapiens
4.1.2.27	FTY720	also called fingolimod	Myxococcus xanthus
4.1.2.27	FTY720	also called fingolimod	Saccharomyces cerevisiae
4.1.2.27	FTY720	also called fingolimod	Symbiobacterium thermophilum
4.1.2.27	LX2931	-	Homo sapiens
4.1.2.27	LX2931	-	Myxococcus xanthus
4.1.2.27	LX2931	-	Saccharomyces cerevisiae
4.1.2.27	LX2931	-	Symbiobacterium thermophilum
4.1.2.27	threo-dihydro-sphingosine 1-phosphate	-	Homo sapiens
4.1.2.27	threo-dihydro-sphingosine 1-phosphate	-	Myxococcus xanthus
4.1.2.27	threo-dihydro-sphingosine 1-phosphate	-	Saccharomyces cerevisiae
4.1.2.27	threo-dihydro-sphingosine 1-phosphate	-	Symbiobacterium thermophilum
4.1.2.27	Zn2+	-	Homo sapiens
4.1.2.27	Zn2+	-	Myxococcus xanthus
4.1.2.27	Zn2+	-	Saccharomyces cerevisiae
4.1.2.27	Zn2+	-	Symbiobacterium thermophilum

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
4.1.2.27	membrane	-	Homo sapiens	16020	-
4.1.2.27	membrane	-	Saccharomyces cerevisiae	16020	-
4.1.2.27	membrane	-	Myxococcus xanthus	16020	-
4.1.2.27	membrane	-	Symbiobacterium thermophilum	16020	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.2.27	Homo sapiens	-	-	-
4.1.2.27	Myxococcus xanthus	-	-	-
4.1.2.27	Saccharomyces cerevisiae	-	-	-
4.1.2.27	Symbiobacterium thermophilum	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.2.27	colon	-	Homo sapiens	-
4.1.2.27	intestine	-	Homo sapiens	-
4.1.2.27	liver	-	Homo sapiens	-
4.1.2.27	additional information	the human SGPL1 gene is ubiquitously expressed with the exception of erythrocytes and platelets and its expression is linked to tissues undergoing rapid cell turnover	Homo sapiens	-
4.1.2.27	thymus	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
4.1.2.27	sphingosine 1-phosphate	-	Homo sapiens	phosphoethanolamine + (2E)-hexadecenal	-	ir
4.1.2.27	sphingosine 1-phosphate	-	Saccharomyces cerevisiae	phosphoethanolamine + (2E)-hexadecenal	-	ir
4.1.2.27	sphingosine 1-phosphate	-	Myxococcus xanthus	phosphoethanolamine + (2E)-hexadecenal	-	ir
4.1.2.27	sphingosine 1-phosphate	-	Symbiobacterium thermophilum	phosphoethanolamine + (2E)-hexadecenal	-	ir

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.2.27	Dpl1p	-	Saccharomyces cerevisiae
4.1.2.27	sphingosine-1-phosphate lyase	-	Homo sapiens
4.1.2.27	sphingosine-1-phosphate lyase	-	Saccharomyces cerevisiae
4.1.2.27	sphingosine-1-phosphate lyase	-	Myxococcus xanthus
4.1.2.27	sphingosine-1-phosphate lyase	-	Symbiobacterium thermophilum
4.1.2.27	SPL	-	Homo sapiens
4.1.2.27	SPL	-	Saccharomyces cerevisiae
4.1.2.27	SPL	-	Myxococcus xanthus
4.1.2.27	SPL	-	Symbiobacterium thermophilum

Cofactor

EC Number	Cofactor	Comment	Organism
4.1.2.27	pyridoxal 5'-phosphate	dependent on	Homo sapiens
4.1.2.27	pyridoxal 5'-phosphate	dependent on	Saccharomyces cerevisiae
4.1.2.27	pyridoxal 5'-phosphate	dependent on	Myxococcus xanthus
4.1.2.27	pyridoxal 5'-phosphate	dependent on	Symbiobacterium thermophilum

Expression

EC Number	Organism	Comment	Expression
4.1.2.27	Homo sapiens	SGPL1 gene expression is downregulated in colon cancer and is upregulated in certain malignant tissues, for example, in ovarian cancers as well as in the skin of patients suffering from atopic dermatitis	down

General Information

EC Number	General Information	Comment	Organism
4.1.2.27	metabolism	SPL functions as the exit gate of the sphingolipid metabolism	Homo sapiens
4.1.2.27	metabolism	SPL functions as the exit gate of the sphingolipid metabolism	Saccharomyces cerevisiae
4.1.2.27	metabolism	SPL functions as the exit gate of the sphingolipid metabolism	Myxococcus xanthus
4.1.2.27	metabolism	SPL functions as the exit gate of the sphingolipid metabolism	Symbiobacterium thermophilum
4.1.2.27	physiological function	SPL plays a crucial role in the migration of T-cells from lymphoid tissues by maintaining the sphingosine 1-phosphate gradient necessary for T-cells to egress from the lymph nodes into the blood stream. SPL plays a central role in neutrophil egress from blood to tissues. SPL is a central and crucial regulator of lipid homeostasis. SPL activity is linked to an increase in CER levels in response to stress factors and is involved in apoptosis	Homo sapiens