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Literature summary extracted from

  • van Dijk, E.; Le Hir, H.; Séraphin, B.
    DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway (2003), Proc. Natl. Acad. Sci. USA, 100, 12081-12086.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.59 7-methylguanosine 5'-diphosphate + H2O Homo sapiens eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA 7-methylguanosine 5'-phosphate + phosphate
-
 ?
3.6.1.59 m7G5'ppp5'N(3'ppp5'N)n + H2O Homo sapiens n = 1-8, eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.59 Homo sapiens Q96C86
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.59 HEK-293 cell
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 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.59 7-methylguanosine 5'-diphosphate + H2O
-
 Homo sapiens 7-methylguanosine 5'-phosphate + phosphate
-
 ?
3.6.1.59 7-methylguanosine 5'-diphosphate + H2O eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA Homo sapiens 7-methylguanosine 5'-phosphate + phosphate
-
 ?
3.6.1.59 m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8 Homo sapiens 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
-
 ?
3.6.1.59 m7G5'ppp5'N(3'ppp5'N)n + H2O n = 1-8, eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the recently identified human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce m7GDP and 5'-phosphorylated mRNA Homo sapiens 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.59 Dcps
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.59 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.59 8
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.6.1.59 physiological function eukaryotic mRNA degradation proceeds through two main pathways, both involving mRNA cap breakdown. In the 3'-5' mRNA decay pathway, mRNA body degradation generates free m7GpppN that is hydrolyzed by DcpS generating m7GMP. In the 5'-3' pathway, the human Dcp2 decapping enzyme cleaves the cap of deadenylated mRNAs to produce 7-methylguanosine 5'-diphosphate and 5'-phosphorylated mRNA Homo sapiens