Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bourrellier, A.; Valot, B.; Guillot, A.; Ambard-Bretteville, F.; Vidal, J.; Hodges, M.
    Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit (2010), Proc. Natl. Acad. Sci. USA, 107, 502-507.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 Avidin general inhibitor of ACCase activity Arabidopsis thaliana
6.4.1.2 fenoxaprop a specific inhibitor of the cytosolic ACCase, does not affect the activity of chloroplast ACCase Arabidopsis thaliana
6.4.1.2 PII protein recombinant Arabidopsis PII protein inhibits chloroplastic ACCase activity dose-dependently and noncompetitively via binding to its BCCP subunit, and this is completely reversed in the presence of 2-oxoglutarate, pyruvate, or oxaloacetate. PII protein decreases the Vmax of the ACCase reaction without altering the Km for acetyl-CoA Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 chloroplast
-
Arabidopsis thaliana 9507
-
6.4.1.2 cytosol
-
Arabidopsis thaliana 5829
-
6.4.1.2 plastid
-
Arabidopsis thaliana 9536
-

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Arabidopsis thaliana
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 leaf
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
Arabidopsis thaliana ADP + malonyl-CoA + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
6.4.1.2 ACCase
-
Arabidopsis thaliana
6.4.1.2 BCCP1 ACCase subunit Arabidopsis thaliana
6.4.1.2 BCCP2 ACCase subunit Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
Arabidopsis thaliana
6.4.1.2 biotin
-
Arabidopsis thaliana

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.4.1.2 0.00015
-
apparent value, in 100 mM Tricine (pH 8.2), at 30°C Arabidopsis thaliana PII protein

General Information

EC Number General Information Comment Organism
6.4.1.2 physiological function ACCase is a key enzyme initiating the synthesis of fatty acids in plastids Arabidopsis thaliana