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Literature summary extracted from

  • Watschinger, K.; Keller, M.A.; Golderer, G.; Hermann, M.; Maglione, M.; Sarg, B.; Lindner, H.H.; Hermetter, A.; Werner-Felmayer, G.; Konrat, R.; Hulo, N.; Werner, E.R.
    Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes (2010), Proc. Natl. Acad. Sci. USA, 107, 13672-13677.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.5 expressed in CHO cell, expressed in Xenopus laevis oocyte, GFP fusion protein expressed in CHO cell, 6x myc tag version expressed in CHO-K1 cell Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.16.5 additional information mutation of each of 8 conserved His residues (to alanine) which are all essential for activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.5 1,10-phenanthroline
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.5 0.00258
-
 tetrahydrobiopterin measured in CHO cells after transfection, pH not specified in the publication, 37°C Homo sapiens
1.14.16.5 0.011
-
 1-O-pyrenedecyl-sn-glycerol measured in CHO cells after transfection, pH not specified in the publication, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.5 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.5 1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2
-
 Homo sapiens glycerol + pyrenedecanal + 6,7[8H]-dihydrobiopterin + H2O
-
 ?
1.14.16.5 alkylglycerol + tetrahydrobiopterin + O2
-
 Homo sapiens glycerol + fatty aldehyde + 6,7[8H]-dihydrobiopterin + H2O after rapid decay of the resulting unstable primary product (hemiacetal) ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.5 alkylglycerol monooxygenase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.16.5 0.00139
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 1,10-phenanthroline