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Literature summary extracted from

  • Wandernoth, P.M.; Raubuch, M.; Mannowetz, N.; Becker, H.M.; Deitmer, J.W.; Sly, W.S.; Wennemuth, G.
    Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm (2010), PLoS ONE, 5, e15061.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 cell surface murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis Mus musculus 9986
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4.2.1.1 extracellular murine sperm possesses extracellular isozyme CA IV that is transferred to the sperm surface as the sperm pass through the epididymis, the transfer takes place in the corpus epididymidis Mus musculus
-
-
4.2.1.1 intracellular
-
 Homo sapiens 5622
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4.2.1.1 plasma membrane apical and basal plasma membrane of proximal tubuli Mus musculus 5886
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Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Homo sapiens
-
-
-
4.2.1.1 Mus musculus
-
-
-
4.2.1.1 Mus musculus C57/BL6J
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 epididymis corpus and cauda Mus musculus
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4.2.1.1 kidney apical and basal plasma membrane of proximal tubuli Mus musculus
-
4.2.1.1 spermatozoon
-
 Mus musculus
-
4.2.1.1 spermatozoon
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 CA IV
-
 Mus musculus
4.2.1.1 carbonic anhydrase IV
-
 Mus musculus
4.2.1.1 carbonic anhydrase IV
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
4.2.1.1 malfunction CA IV-/- mice show a 32.13% reduction in total carbonic anhydrase activity and reduced beat frequency compared to the wild-type Mus musculus
4.2.1.1 physiological function role of isozyme carbonic anhydrase IV in the bicarbonate-mediated activation of sperm, overview. Sperm respond to CO2 with an increase in beat frequency, an effect that can be inhibited by ethoxyzolamide. CA IV supplies sperm with HCO3-, which is necessary for stimulation of atypical sperm adenylyl cyclase and hence early activation of spermatozoa Mus musculus
4.2.1.1 physiological function role of isozyme carbonic anhydrase IV in the bicarbonate-mediated activation of sperm, overview. Sperm respond to CO2 with an increase in beat frequency, an effect that can be inhibited by ethoxyzolamide. CA IV supplies sperm with HCO3-, which is necessary for stimulation of atypical sperm adenylyl cyclase and hence early activation of spermatozoa Homo sapiens