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Literature summary extracted from

  • Simsek, D.; Brunet, E.; Wong, S.Y.; Katyal, S.; Gao, Y.; McKinnon, P.J.; Lou, J.; Zhang, L.; Li, J.; Rebar, E.J.; Gregory, P.D.; Holmes, M.C.; Jasin, M.
    DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation (2011), PLoS Genet., 7, e1002080.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.5.1.1 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Mus musculus AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase III
-
 Mus musculus
6.5.1.1 Lig3
-
 Mus musculus

General Information

EC Number General Information Comment Organism
6.5.1.1 malfunction deletion of Lig3 results in cellular lethality. Translocations are reduced in frequency in the absence of Lig3. alternative nonhomologous end-joining is impaired with Lig3 loss. Deletion of the zinc finger domain of Lig3, but not the XRCC1-interacting BRCT domain, affects translocation frequency and outcome Mus musculus
6.5.1.1 physiological function Lig3 promotes alternative nonhomologous end-joining during chromosomal translocation formation. Lig3 is essential for mitochondrial DNA metabolism Mus musculus