Literature summary extracted from

Bailly, A.P.; Freeman, A.; Hall, J.; Declais, A.C.; Alpi, A.; Lilley, D.M.; Ahmed, S.; Gartner, A.
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair (2010), PLoS Genet., 6, e1001025.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.21.10	gene gen-1, DNA and amino acid sequence determination and analysis. GEN-1 assignment and phylogenetic relationships	Caenorhabditis elegans

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.1.21.10	additional information	gen-1 mutants are defective in DNA damage-dependent cell cycle arrest and apoptosis and in positional cloning of GEN-1, phenotypes, detailed overview	Caenorhabditis elegans

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.21.10	Caenorhabditis elegans	-	gene gen-1	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.21.10	Gen-1	-	Caenorhabditis elegans
3.1.21.10	Holliday junction resolving enzyme	-	Caenorhabditis elegans

General Information

EC Number	General Information	Comment	Organism
3.1.21.10	malfunction	gen-1 mutants are defective in DNA damage-dependent cell cycle arrest and apoptosis and in positional cloning of GEN-1, phenotypes, detailed overview	Caenorhabditis elegans
3.1.21.10	metabolism	gen-1 acts in a non-canonical DNA damage checkpoint pathway	Caenorhabditis elegans
3.1.21.10	physiological function	identification of a Caenorhabditis elegans dual function DNA double-strand break repair and DNA damage signaling protein orthologous to the human GEN1 Holliday junction resolving enzyme. GEN-1 is required for DNA double-strand break repair. The DNA damage-signaling function of GEN-1 is separable from its role in DNA repair. GEN-1 promotes germ cell cycle arrest and apoptosis via a pathway that acts in parallel to the canonical DNA damage response pathway mediated by RPA loading, CHK1 activation, and CEP-1/p53-mediated apoptosis induction. GEN-1 acts redundantly with the 9-1-1 complex to ensure genome stability. GEN-1 might act as a dual function Holliday junction resolvase that may coordinate DNA damage signaling with a late step in DNA double-strand break repair	Caenorhabditis elegans

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Release 2023.1 (January 2023)