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Literature summary extracted from

  • Degu, A.; Hatew, B.; Nunes-Nesi, A.; Shlizerman, L.; Zur, N.; Katz, E.; Fernie, A.R.; Blumwald, E.; Sadka, A.
    Inhibition of aconitase in Citrus fruit callus results in a metabolic shift towards amino acid biosynthesis (2011), Planta, 234, 501-513.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.3 citramalate an endogenous compound of fruit pulp, is a competitive endogenous inhibitor of citrus aconitase, it significantly increases citrate content and reduces the mitochondrial isozyme activity, while slightly inducing its protein level Citrus limon
4.2.1.3 Oxalomalate significantly increases citrate content and reduces the enzyme's activity, while slightly inducing its protein level. Specific activities of amino acid-metabolizing enzymes are induced in oxalomalate-treated callus cells, overview Citrus limon

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.3 cytosol soluble isozyme Citrus limon 5829
-
4.2.1.3 mitochondrion mitochondrial isozyme Citrus limon 5739
-

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.3 Citrus limon
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.3 callus from fruit juice cells Citrus limon
-
4.2.1.3 fruit
-
 Citrus limon
-

Expression

EC Number Organism Comment Expression
4.2.1.3 Citrus limon citramalate significantly increases citrate content and reduces the mitochondrial isozyme activity, while slightly inducing its protein level, oxalomalate also slightly upregulates the enzyme up

General Information

EC Number General Information Comment Organism
4.2.1.3 physiological function the increase in citrate, caused by aconitase inhibition, induces amino acid synthesis and the gamma-aminobutyrate shunt, in accordance with the suggested fate of citrate during the acid decline stage in citrus fruit Citrus limon