BRENDA - Enzyme Database

Alkaloids from roots of Stephania rotunda and their cholinesterase inhibitory activity

Hung, T.M.; Dang, N.H.; Kim, J.C.; Jang, H.S.; Ryoo, S.W.; Lee, J.H.; Choi, J.S.; Bae, K.; Min, B.S.; Planta Med. 76, 1762-1764 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.7
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
Rattus norvegicus
3.1.1.7
isocorydine
-
Rattus norvegicus
3.1.1.7
oxoxylopine
-
Rattus norvegicus
3.1.1.7
palmatine
-
Rattus norvegicus
3.1.1.7
remerine
-
Rattus norvegicus
3.1.1.7
stepharotudine
-
Rattus norvegicus
3.1.1.7
tacrine
-
Rattus norvegicus
3.1.1.7
tetrahydropalmatine
-
Rattus norvegicus
3.1.1.7
thalifoline
-
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.7
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.7
brain cortex
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.7
acetylthiocholine + H2O
-
716639
Rattus norvegicus
thiocholine + acetate
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.1.1.7
0.00017
-
pH and temperature not specified in the publication
Rattus norvegicus
tacrine
3.1.1.7
0.0104
-
pH and temperature not specified in the publication
Rattus norvegicus
palmatine
3.1.1.7
0.0184
-
pH and temperature not specified in the publication
Rattus norvegicus
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
3.1.1.7
0.0207
-
pH and temperature not specified in the publication
Rattus norvegicus
remerine
3.1.1.7
0.038
-
pH and temperature not specified in the publication
Rattus norvegicus
stepharotudine
3.1.1.7
0.0413
-
pH and temperature not specified in the publication
Rattus norvegicus
tetrahydropalmatine
3.1.1.7
0.0425
-
pH and temperature not specified in the publication
Rattus norvegicus
oxoxylopine
3.1.1.7
0.05
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
Rattus norvegicus
isocorydine
3.1.1.7
0.05
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
Rattus norvegicus
thalifoline
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
3.1.1.7
0.00017
-
pH and temperature not specified in the publication
Rattus norvegicus
tacrine
3.1.1.7
0.0104
-
pH and temperature not specified in the publication
Rattus norvegicus
palmatine
3.1.1.7
0.0184
-
pH and temperature not specified in the publication
Rattus norvegicus
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
3.1.1.7
0.0207
-
pH and temperature not specified in the publication
Rattus norvegicus
remerine
3.1.1.7
0.038
-
pH and temperature not specified in the publication
Rattus norvegicus
stepharotudine
3.1.1.7
0.0413
-
pH and temperature not specified in the publication
Rattus norvegicus
tetrahydropalmatine
3.1.1.7
0.0425
-
pH and temperature not specified in the publication
Rattus norvegicus
oxoxylopine
3.1.1.7
0.05
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
Rattus norvegicus
isocorydine
3.1.1.7
0.05
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
Rattus norvegicus
thalifoline
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.7
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
Rattus norvegicus
3.1.1.7
isocorydine
-
Rattus norvegicus
3.1.1.7
oxoxylopine
-
Rattus norvegicus
3.1.1.7
palmatine
-
Rattus norvegicus
3.1.1.7
remerine
-
Rattus norvegicus
3.1.1.7
stepharotudine
-
Rattus norvegicus
3.1.1.7
tacrine
-
Rattus norvegicus
3.1.1.7
tetrahydropalmatine
-
Rattus norvegicus
3.1.1.7
thalifoline
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.7
brain cortex
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.7
acetylthiocholine + H2O
-
716639
Rattus norvegicus
thiocholine + acetate
-
-
-
?