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Literature summary extracted from

  • Hung, T.M.; Dang, N.H.; Kim, J.C.; Jang, H.S.; Ryoo, S.W.; Lee, J.H.; Choi, J.S.; Bae, K.; Min, B.S.
    Alkaloids from roots of Stephania rotunda and their cholinesterase inhibitory activity (2010), Planta Med., 76, 1762-1764.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
 Rattus norvegicus
3.1.1.7 isocorydine
-
 Rattus norvegicus
3.1.1.7 oxoxylopine
-
 Rattus norvegicus
3.1.1.7 palmatine
-
 Rattus norvegicus
3.1.1.7 remerine
-
 Rattus norvegicus
3.1.1.7 stepharotudine
-
 Rattus norvegicus
3.1.1.7 tacrine
-
 Rattus norvegicus
3.1.1.7 tetrahydropalmatine
-
 Rattus norvegicus
3.1.1.7 thalifoline
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 brain cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Rattus norvegicus thiocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.00017
-
 pH and temperature not specified in the publication Rattus norvegicus tacrine
3.1.1.7 0.0104
-
 pH and temperature not specified in the publication Rattus norvegicus palmatine
3.1.1.7 0.0184
-
 pH and temperature not specified in the publication Rattus norvegicus 7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
3.1.1.7 0.0207
-
 pH and temperature not specified in the publication Rattus norvegicus remerine
3.1.1.7 0.038
-
 pH and temperature not specified in the publication Rattus norvegicus stepharotudine
3.1.1.7 0.0413
-
 pH and temperature not specified in the publication Rattus norvegicus tetrahydropalmatine
3.1.1.7 0.0425
-
 pH and temperature not specified in the publication Rattus norvegicus oxoxylopine
3.1.1.7 0.05
-
 IC50 above 0.05 mM, pH and temperature not specified in the publication Rattus norvegicus isocorydine
3.1.1.7 0.05
-
 IC50 above 0.05 mM, pH and temperature not specified in the publication Rattus norvegicus thalifoline