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Literature summary extracted from

  • Brumshtein, B.; Aguilar-Moncayo, M.; Benito, J.M.; Garcia Fernandez, J.M.; Silman, I.; Shaaltiel, Y.; Aviezer, D.; Sussman, J.L.; Futerman, A.H.; Ortiz Mellet, C.
    Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues (2011), Org. Biomol. Chem., 9, 4160-4167.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.2.1.45 in complex beta-cyclodextrin and either 5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin or 5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin, microbatch under oil method, using 0.2 M (NH4)2SO4, 0.1 M Tris pH 6.5, and 25% (w/v) PEG3350 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.45 5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin potent inhibitor Homo sapiens
3.2.1.45 5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thionojirimycin potent inhibitor Homo sapiens
3.2.1.45 6-amino-6-deoxy-5-N,6-N-[N'-(n-octyl)iminomethylidene]nojirimycin
-
 Homo sapiens
3.2.1.45 additional information isofagomine is not specific for the enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.45 lysosome
-
 Homo sapiens 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 glucosylceramide + H2O
-
 Homo sapiens beta-D-glucose + ceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.45 acid beta-glucosidase
-
 Homo sapiens
3.2.1.45 beta-glucocerebrosidase
-
 Homo sapiens
3.2.1.45 GlcCerase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.2.1.45 malfunction mutations in the gene encoding for acid beta-glucosidase result in Gaucher disease Homo sapiens