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Literature summary extracted from

  • Negron, L.; Parker, E.
    Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase (2011), Org. Biomol. Chem., 9, 2861-2867.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.4
-
Escherichia coli
4.2.3.4
-
Pyrococcus furiosus
4.2.3.4
-
Actinidia chinensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.4 0.0016
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 0.002
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 0.0032
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 0.0037
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 0.0057
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 0.0087
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 0.021
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 0.029
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 0.064
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.3.4 37397
-
x * 37397, electrospray ionisation mass spectrometry Pyrococcus furiosus
4.2.3.4 38888
-
x * 38888, electrospray ionisation mass spectrometry Escherichia coli
4.2.3.4 45189
-
x * 45189, electrospray ionisation mass spectrometry, His-tagged protein Actinidia chinensis

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.4 Actinidia chinensis
-
-
-
4.2.3.4 Escherichia coli
-
-
-
4.2.3.4 Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.4 (3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Escherichia coli (6R)-6-fluoro-dehydroquinate
-
?
4.2.3.4 (3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Pyrococcus furiosus (6R)-6-fluoro-dehydroquinate
-
?
4.2.3.4 (3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Actinidia chinensis (6R)-6-fluoro-dehydroquinate
-
?
4.2.3.4 (3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Escherichia coli (6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate 1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme ?
4.2.3.4 (3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Pyrococcus furiosus (6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate 1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme ?
4.2.3.4 (3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate
-
Actinidia chinensis (6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate 1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme ?
4.2.3.4 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Escherichia coli 3-dehydroquinate + phosphate
-
?
4.2.3.4 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Pyrococcus furiosus 3-dehydroquinate + phosphate
-
?
4.2.3.4 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate
-
Actinidia chinensis 3-dehydroquinate + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
4.2.3.4 ? x * 37397, electrospray ionisation mass spectrometry Pyrococcus furiosus
4.2.3.4 ? x * 38888, electrospray ionisation mass spectrometry Escherichia coli
4.2.3.4 ? x * 45189, electrospray ionisation mass spectrometry, His-tagged protein Actinidia chinensis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.3.4 0.3
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 0.3
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 0.5
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 0.9
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 1.3
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 2.5
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 3
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 3.3
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 16
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Escherichia coli

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.3.4 14
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 14.3
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 34.5
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 44.8
-
(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 156
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Actinidia chinensis
4.2.3.4 811
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 1562
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Escherichia coli
4.2.3.4 1650
-
(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate pH 6.8, 25°C Pyrococcus furiosus
4.2.3.4 2807
-
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate pH 6.8, 25°C Escherichia coli