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Literature summary extracted from

  • Dave, K.; Scozzafava, A.; Vullo, D.; Supuran, C.T.; Ilies, M.A.
    Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII (2011), Org. Biomol. Chem., 9, 2790-2800.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,3,4,6-tetramethylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,4,6-trimethylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,4-dimethyl-6-phenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-iso-propyl-4-methylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-iso-propyl-4-phenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-butyl-4-methylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-butyl-4-phenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-propyl-4-methylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-propyl-4-phenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diethyl-4-methylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diethyl-4-phenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-dimethyl-3,5-(nonane-1,9-diyl)pyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-dimethyl-4-phenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diphenyl-4-methylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-ethyl-4,6-dimethylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-ethyl-4,6-diphenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-iso-propyl-4,6-dimethylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-iso-propyl-4,6-diphenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-methyl-4,6-diphenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-butyl -4,6 -dimethylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-butyl-4,6-diphenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-propyl-4,6-dimethylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-propyl-4,6-diphenylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 4-[2-(4-dimethylaminophenyl)-vinyl]-1-[2-(1H-imidazol-4-yl)ethyl]-2,6-di-isopropylpyridinium hexafluorophosphate
-
Homo sapiens
4.2.1.1 histamine
-
Homo sapiens
4.2.1.1 additional information activating effects on the cytosolic isozymes hCA I, hCA II, and hCA VII, competitive steady-state activation kinetics of the pyridinium histamine derivatives, KA values, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 cytosol cytosolic isozymes hCA I, hCA II, and hCA VII Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+ active site bound and essential for catalysis, metalloenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Homo sapiens
-
CO2 + H2O
-
r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
Homo sapiens CO2 + H2O
-
r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 carbonic anhydrase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.1 25
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.1 7.5
-
assay at Homo sapiens