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Literature summary extracted from

  • Le Bihan, Y.V.; Angeles Izquierdo, M.; Coste, F.; Aller, P.; Culard, F.; Gehrke, T.H.; Essalhi, K.; Carell, T.; Castaing, B.
    5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases (2011), Nucleic Acids Res., 39, 6277-6290.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.23 expressed in Escherichia coli strain BH540 Lactococcus lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.23 DNA containing 2-deoxyribonolactone residues suicide inhibitor for formamidopyrimidine-DNA glycosylase Lactococcus lactis
3.2.2.23 DNA containing 5-hydroxy-5-methylhydantoin residues suicide inhibitor for formamidopyrimidine-DNA glycosylase Lactococcus lactis

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.23 Lactococcus lactis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.23 DNA containing 2,6-diamino-4-hydroxy-5-formamidopyrimidine residues + H2O
-
 Lactococcus lactis 2,6-diamino-4-hydroxy-5-formamidopyrimidine + DNA
-
 ?
3.2.2.23 DNA containing 5-hydroxy-5-methylhydantoin residues opposite cytosine + H2O excellent substrate when the lesion is opposite a cytosine, poor substrate when the lesion is opposite a adenine Lactococcus lactis 5-hydroxy-5-methylhydantoin + DNA
-
 ?
3.2.2.23 DNA containing 8-oxo-7,8-dihydropurine + H2O poor substrate when the lesion is opposite a cytosine Lactococcus lactis 8-oxo-7,8-dihydropurine + DNA
-
 ?
3.2.2.23 additional information the enzyme is a DNA glycosylase/AP lyase specific for oxidized purines such as 8-oxo-7,8-dihydropurines and imidazole-ring opened purines (2,6-diamino-4-hydroxy-5-formamidopyrimidine and formamidopyrimidine derived from adenine) Lactococcus lactis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.23 Fapy DNA glycosylase
-
 Lactococcus lactis
3.2.2.23 formamidopyrimidine-DNA glycosylase
-
 Lactococcus lactis
3.2.2.23 FPG
-
 Lactococcus lactis
3.2.2.23 MutM
-
 Lactococcus lactis