Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Falnes, P.O.
    Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins (2004), Nucleic Acids Res., 32, 6260-6267.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.33 Fe2+ required for activity Escherichia coli
1.14.11.33 Fe2+ required for activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.33 Escherichia coli
-
-
-
1.14.11.33 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.33 DNA-1-methyladenine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-1-methyladenine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-3-methylthymine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-thymine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-3-methylthymine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-thymine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 additional information adenosine, deoxythymine, 3-methyldeoxythymidine, guanosine, 1-methylguanosine, 1-methylguanine and 3-methylthymine do not stimulate AlkB-mediated decarboxylation of 2-oxoglutarate Escherichia coli ?
-
 ?
1.14.11.33 RNA-1-methyladenine + 2-oxoglutarate + O2
-
 Escherichia coli RNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 RNA-1-methyladenine + 2-oxoglutarate + O2
-
 Homo sapiens RNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 RNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Escherichia coli RNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 RNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Homo sapiens RNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 tRNA-1-methylguanine + 2-oxoglutarate + O2
-
 Escherichia coli tRNA-guanine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 tRNA-1-methylguanine + 2-oxoglutarate + O2
-
 Homo sapiens tRNA-guanine + formaldehyde + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.33 ABH2 isoform Homo sapiens
1.14.11.33 ABH3 isoform Homo sapiens
1.14.11.33 AlkB
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.33 2-oxoglutarate
-
 Escherichia coli
1.14.11.33 2-oxoglutarate
-
 Homo sapiens