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Literature summary extracted from

  • Falnes, P.O.; Bjoras, M.; Aas, P.A.; Sundheim, O.; Seeberg, E.
    Substrate specificities of bacterial and human AlkB proteins (2004), Nucleic Acids Res., 32, 3456-3461.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.33 Fe2+ required for activity Escherichia coli
1.14.11.33 Fe2+ required for activity Homo sapiens
1.14.11.33 Mg2+ the double-stranded DNA preference of isoform ABH2 is observed only in the presence of magnesium, the presence of magnesium stimulates the activity of isoform ABH2 on double-stranded DNA, but inhibits its activity on single-stranded DNA (maximal effect is observed in the presence of 10 mM MgCl2) Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.33 Escherichia coli
-
-
-
1.14.11.33 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.33 DNA-1-methyladenine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-1-methyladenine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 DNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 methylated poly(deoxyadenine) + 2-oxoglutarate + O2 the activity of AlkB on methylated poly(deoxyadenine) annealed to unmethylated poly(deoxythymine) is 3fold higher than with methylated poly(deoxyadenine) alone Escherichia coli poly(deoxyadenine) + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 additional information AlkB prefers single-stranded DNA and RNA Escherichia coli ?
-
 ?
1.14.11.33 additional information isoform ABH3 prefers single-stranded DNA (also under magnesium-free conditions) and RNA, while isoform ABH2 prefers double-stranded DNA (only in the presence of magnesium) and RNA Homo sapiens ?
-
 ?
1.14.11.33 RNA-1-methyladenine + 2-oxoglutarate + O2
-
 Escherichia coli RNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 RNA-1-methyladenine + 2-oxoglutarate + O2
-
 Homo sapiens RNA-adenine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 RNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Escherichia coli RNA-cytosine + formaldehyde + succinate + CO2
-
 ?
1.14.11.33 RNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Homo sapiens RNA-cytosine + formaldehyde + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.33 ABH2 isoform Homo sapiens
1.14.11.33 ABH3 isoform Homo sapiens
1.14.11.33 AlkB
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.33 2-oxoglutarate
-
 Escherichia coli
1.14.11.33 2-oxoglutarate
-
 Homo sapiens