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Literature summary extracted from

  • Fernandes, S.P.; Dringen, R.; Lawen, A.; Robinson, S.R.
    Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron (2011), Neurosci. Lett., 490, 27-30.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.2 ascorbate little loss of activity with 2 mM ascorbate alone. Complete inactivation by co-incubation with 1 mM H2O2, 0.002 mM Fe3+, 2 mM ascorbate for 30 min Ovis aries
6.3.1.2 Fe3+ no loss of activity with 0.002 mM Fe3+ alone. Complete inactivation by co-incubation with 1 mM H2O2, 0.002 mM Fe3+, 2 mM ascorbate for 30 min Ovis aries
6.3.1.2 H2O2 1 mM, 3 h, 63% loss of activity. Inactivation is prevented by the iron chelators 2,2'-dipyridylor 1,10-phenanthroline, but not by their non-chelating analogues Mus musculus
6.3.1.2 H2O2 1 mM, 30 min, 41% loss of activity. Complete inactivation by co-incubation with 1 mM H2O2, 0.002 mM Fe3+, 2 mM ascorbate for 30 min Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.2 Mus musculus
-
-
-
6.3.1.2 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.1.2 astrocyte primary cell culture Mus musculus
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6.3.1.2 brain
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Ovis aries
-