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Literature summary extracted from

  • Gao, M.H.; Tang, T.; Lai, N.C.; Miyanohara, A.; Guo, T.; Tang, R.; Firth, A.L.; Yuan, J.X.; Hammond, H.K.
    Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant (2011), Mol. Pharmacol., 79, 381-388.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.1 D425A catalytically inactive mutant of isoform AC6, the expression of the mutant is associated with marked reduction in cAMP production Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 cardiac myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC6 isoform Rattus norvegicus
4.6.1.1 adenylyl cyclase type 6
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.6.1.1 Calmodulin
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
4.6.1.1 Rattus norvegicus isoform AC6 expression is stimulated by forskolin and isoproterenol (0.01 mM) up