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Literature summary extracted from
- HdcB, a novel enzyme catalysing maturation of pyruvoyl-dependent histidine decarboxylase (2011), Mol. Microbiol., 79, 861-871.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.22 | HdcB | HdcB catalyses the maturation of pyruvoyl-dependent histidine decarboxylase by cleavage of the proenzyme which results in the formation of the pyruvoyl prosthetic group | Streptococcus thermophilus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.22 | expressed in Lactococcus lactis strain NZ9000 and Escherichia coli DH5alpha cells | Streptococcus thermophilus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.1.1.22 | S82A | the HdcA mutant mimics the proenzyme | Streptococcus thermophilus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.22 | 12000 | - |
1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE | Streptococcus thermophilus |
| 4.1.1.22 | 24000 | - |
1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE | Streptococcus thermophilus |
| 4.1.1.22 | 37000 | - |
x * 37000, uncleaved proenzyme, SDS-PAGE | Streptococcus thermophilus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.22 | Streptococcus thermophilus | - |
CHCC1524 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.22 | Ni2+-NTA column chromatography | Streptococcus thermophilus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.22 | L-histidine | - |
Streptococcus thermophilus | histamine + CO2 | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.22 | ? | x * 37000, uncleaved proenzyme, SDS-PAGE | Streptococcus thermophilus |
| 4.1.1.22 | heterodimer | 1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE | Streptococcus thermophilus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.22 | HdcA | - |
Streptococcus thermophilus |
| 4.1.1.22 | pyruvoyl-dependent histidine decarboxylase | - |
Streptococcus thermophilus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.22 | Pyruvoyl group | dependent on | Streptococcus thermophilus | |
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Release 2023.1 (January 2023)
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