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Literature summary extracted from

  • Stead, C.; Zhao, J.; Raetz, C.; Trent, M.
    Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface (2010), Mol. Microbiol., 78, 837-852.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.124 expressed in Escherichia coli HMS174 cells Helicobacter pylori

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.124 Helicobacter pylori
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.124 1-dephosphorylated Kdo2-lipid A + H2O
-
 Helicobacter pylori ?
-
 ?
3.2.1.124 Kdo2-lipid A + H2O
-
 Helicobacter pylori ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.124 3-deoxy-D-manno-octulosonic acid hydrolase
-
 Helicobacter pylori
3.2.1.124 Hp0580
-
 Helicobacter pylori
3.2.1.124 Kdo hydrolase
-
 Helicobacter pylori

General Information

EC Number General Information Comment Organism
3.2.1.124 malfunction inactivation of Kdo hydrolase activity produces two phenotypes associated with cationic antimicrobial peptide resistance and O-antigen expression. Kdo hydrolase mutants are highly sensitive to polymyxin B. Production of a fully extended O-antigen is also diminished in a Kdo hydrolase mutant, with a consequent increase in core-lipid A Helicobacter pylori
3.2.1.124 physiological function Kdo hydrolase plays a role in the maintenance of the bacterial surface. Kdo hydrolase activity modulates O-antigen expression Helicobacter pylori