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Literature summary extracted from

  • Soeda, Y.; Tsuneki, H.; Muranaka, H.; Mori, N.; Hosoh, S.; Ichihara, Y.; Kagawa, S.; Wang, X.; Toyooka, N.; Takamura, Y.; Uwano, T.; Nishijo, H.; Wada, T.; Sasaoka, T.
    The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain (2010), Mol. Endocrinol., 24, 1965-1977.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.36 additional information transgenic mice overexpressing SHIP2 show increased amounts of SHIP2 inducing the disruption of insulin/IGF-I signaling through Akt. Neuroprotective effects of insulin and IGF-I are significantly attenuated in cultured cerebellar granule neurons from SHIP2 transgenic mice, the number of apoptosis-positive cells is increased in cerebral cortex of the transgenic mice at an elderly age, phenotype, overview Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.36 Mus musculus Q6P549
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3.1.3.36 Mus musculus C57/BL6J Q6P549
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.36 brain widely expressed in adult mouse brain. SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice, semiquantitative RT-PCR expression analysis Mus musculus
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3.1.3.36 neuron
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Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
3.1.3.36 inositol phosphatase
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Mus musculus
3.1.3.36 SH2-containing inositol 5'-phosphatase 2
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Mus musculus
3.1.3.36 SHIP2
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Mus musculus

Expression

EC Number Organism Comment Expression
3.1.3.36 Mus musculus SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice up

General Information

EC Number General Information Comment Organism
3.1.3.36 malfunction excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin resistance with type 2 diabetes. A dominant-negative mutant of SHIP2, expressed in cultured neurons, causes insulin signaling augmentation. Inhibition of SHIP2 ameliorates the impairment of hippocampal synaptic plasticity and memory formation in db/db mice Mus musculus
3.1.3.36 physiological function SH2-containing inositol 5'-phosphatase 2, i.e. SHIP2, is a negative regulator of phosphatidylinositol 3,4,5-trisphosphate-mediated signals and shows physiological significance in neurons Mus musculus