EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.36 | additional information | transgenic mice overexpressing SHIP2 show increased amounts of SHIP2 inducing the disruption of insulin/IGF-I signaling through Akt. Neuroprotective effects of insulin and IGF-I are significantly attenuated in cultured cerebellar granule neurons from SHIP2 transgenic mice, the number of apoptosis-positive cells is increased in cerebral cortex of the transgenic mice at an elderly age, phenotype, overview | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.36 | Mus musculus | Q6P549 | - |
- |
3.1.3.36 | Mus musculus C57/BL6J | Q6P549 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.36 | brain | widely expressed in adult mouse brain. SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice, semiquantitative RT-PCR expression analysis | Mus musculus | - |
3.1.3.36 | neuron | - |
Mus musculus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.36 | inositol phosphatase | - |
Mus musculus |
3.1.3.36 | SH2-containing inositol 5'-phosphatase 2 | - |
Mus musculus |
3.1.3.36 | SHIP2 | - |
Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.1.3.36 | Mus musculus | SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.36 | malfunction | excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin resistance with type 2 diabetes. A dominant-negative mutant of SHIP2, expressed in cultured neurons, causes insulin signaling augmentation. Inhibition of SHIP2 ameliorates the impairment of hippocampal synaptic plasticity and memory formation in db/db mice | Mus musculus |
3.1.3.36 | physiological function | SH2-containing inositol 5'-phosphatase 2, i.e. SHIP2, is a negative regulator of phosphatidylinositol 3,4,5-trisphosphate-mediated signals and shows physiological significance in neurons | Mus musculus |