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Literature summary extracted from

  • Purohit, A.; Woo, L.W.; Potter, B.V.
    Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism (2011), Mol. Cell. Endocrinol., 340, 154-160.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 irosustat i.e. BN83495 Homo sapiens
3.1.6.2 additional information inhibitor development of the enzyme in cancer treatment, clinical studies, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 dehydroepiandrosterone sulfate + H2O Homo sapiens dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 estrone sulfate + H2O Homo sapiens
-
 estrone + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 breast carcinoma cell
-
 Homo sapiens
-
3.1.6.2 additional information enzyme activity is reduced in menopausal women Homo sapiens
-
3.1.6.2 uterine endometrial carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 dehydroepiandrosterone sulfate + H2O dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 steroid sulfatase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.6.2 metabolism relevance and interplay between aromatase, steroid sulfatase, organic anion transporting polypeptide B, and 17beta-hydroxysteroid dehydrogenase type 1 to facilitate local synthesis of estrogenic steroids within breast and other tissues, pathways of local synthesis of estrogenic steroids in neoplastic breast tissue, overview Homo sapiens