BRENDA - Enzyme Database show

Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism

Purohit, A.; Woo, L.W.; Potter, B.V.; Mol. Cell. Endocrinol. 340, 154-160 (2011)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
irosustat
i.e. BN83495
Homo sapiens
3.1.6.2
additional information
inhibitor development of the enzyme in cancer treatment, clinical studies, overview
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.6.2
membrane
-
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
dehydroepiandrosterone sulfate + H2O
Homo sapiens
dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol
dehydroepiandrosterone + sulfate
-
-
?
3.1.6.2
estrone sulfate + H2O
Homo sapiens
-
estrone + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
breast carcinoma cell
-
Homo sapiens
-
3.1.6.2
additional information
enzyme activity is reduced in menopausal women
Homo sapiens
-
3.1.6.2
uterine endometrial carcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
dehydroepiandrosterone sulfate + H2O
-
716214
Homo sapiens
dehydroepiandrosterone + sulfate
-
-
-
?
3.1.6.2
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol
716214
Homo sapiens
dehydroepiandrosterone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
-
716214
Homo sapiens
estrone + sulfate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
irosustat
i.e. BN83495
Homo sapiens
3.1.6.2
additional information
inhibitor development of the enzyme in cancer treatment, clinical studies, overview
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.6.2
membrane
-
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
dehydroepiandrosterone sulfate + H2O
Homo sapiens
dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol
dehydroepiandrosterone + sulfate
-
-
?
3.1.6.2
estrone sulfate + H2O
Homo sapiens
-
estrone + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
breast carcinoma cell
-
Homo sapiens
-
3.1.6.2
additional information
enzyme activity is reduced in menopausal women
Homo sapiens
-
3.1.6.2
uterine endometrial carcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
dehydroepiandrosterone sulfate + H2O
-
716214
Homo sapiens
dehydroepiandrosterone + sulfate
-
-
-
?
3.1.6.2
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol
716214
Homo sapiens
dehydroepiandrosterone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
-
716214
Homo sapiens
estrone + sulfate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.1.6.2
metabolism
relevance and interplay between aromatase, steroid sulfatase, organic anion transporting polypeptide B, and 17beta-hydroxysteroid dehydrogenase type 1 to facilitate local synthesis of estrogenic steroids within breast and other tissues, pathways of local synthesis of estrogenic steroids in neoplastic breast tissue, overview
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.6.2
metabolism
relevance and interplay between aromatase, steroid sulfatase, organic anion transporting polypeptide B, and 17beta-hydroxysteroid dehydrogenase type 1 to facilitate local synthesis of estrogenic steroids within breast and other tissues, pathways of local synthesis of estrogenic steroids in neoplastic breast tissue, overview
Homo sapiens