BRENDA - Enzyme Database show

Steroid sulfatase and estrogen sulfotransferase in human carcinomas

Suzuki, T.; Miki, Y.; Nakamura, Y.; Ito, K.; Sasano, H.; Mol. Cell. Endocrinol. 340, 148-153 (2011)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.8.2.4
medicine
enzyme immunoreactivity is inversely correlated with tumor size or lymph node status in the invasive breast carcinoma, and is also significantly associated with a decreased risk of recurrence or improved prognosis of the patients. Ovarian cancer patients with higher enzyme activity are significantly associated with shorter progression-free survival than those with lower enzyme activity
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.4
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
?
3.1.6.2
estrone sulfate + H2O
Homo sapiens
estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase
estrone + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.4
Homo sapiens
-
-
-
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
breast carcinoma cell
-
Homo sapiens
-
2.8.2.4
colonic carcinoma cell
-
Homo sapiens
-
2.8.2.4
endometrial carcinoma cell
-
Homo sapiens
-
2.8.2.4
additional information
the enzyme is not detected in non-neoplastic prostate tissues
Homo sapiens
-
2.8.2.4
ovarian carcinoma cell
-
Homo sapiens
-
2.8.2.4
prostate carcinoma cell
-
Homo sapiens
-
3.1.6.2
breast carcinoma cell
steroid sulfatase enzyme activity is detected in the great majority of breast carcinomas
Homo sapiens
-
3.1.6.2
carcinoma cell
-
Homo sapiens
-
3.1.6.2
colonic cancer cell
-
Homo sapiens
-
3.1.6.2
endometrial cancer cell
-
Homo sapiens
-
3.1.6.2
ovary cancer cell
-
Homo sapiens
-
3.1.6.2
prostate gland cancer cell
-
Homo sapiens
-
3.1.6.2
uterine endometrial carcinoma cell
-
Homo sapiens
-
3.1.6.2
uterine endometrium
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
716213
Homo sapiens
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
-
716213
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase
716213
Homo sapiens
estrone + sulfate
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
2.8.2.4
medicine
enzyme immunoreactivity is inversely correlated with tumor size or lymph node status in the invasive breast carcinoma, and is also significantly associated with a decreased risk of recurrence or improved prognosis of the patients. Ovarian cancer patients with higher enzyme activity are significantly associated with shorter progression-free survival than those with lower enzyme activity
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.4
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
Homo sapiens
-
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
?
3.1.6.2
estrone sulfate + H2O
Homo sapiens
estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase
estrone + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.4
breast carcinoma cell
-
Homo sapiens
-
2.8.2.4
colonic carcinoma cell
-
Homo sapiens
-
2.8.2.4
endometrial carcinoma cell
-
Homo sapiens
-
2.8.2.4
additional information
the enzyme is not detected in non-neoplastic prostate tissues
Homo sapiens
-
2.8.2.4
ovarian carcinoma cell
-
Homo sapiens
-
2.8.2.4
prostate carcinoma cell
-
Homo sapiens
-
3.1.6.2
breast carcinoma cell
steroid sulfatase enzyme activity is detected in the great majority of breast carcinomas
Homo sapiens
-
3.1.6.2
carcinoma cell
-
Homo sapiens
-
3.1.6.2
colonic cancer cell
-
Homo sapiens
-
3.1.6.2
endometrial cancer cell
-
Homo sapiens
-
3.1.6.2
ovary cancer cell
-
Homo sapiens
-
3.1.6.2
prostate gland cancer cell
-
Homo sapiens
-
3.1.6.2
uterine endometrial carcinoma cell
-
Homo sapiens
-
3.1.6.2
uterine endometrium
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.4
3'-phosphoadenylylsulfate + estrone
-
716213
Homo sapiens
adenosine 3',5'-bisphosphate + estrone sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
-
716213
Homo sapiens
estrone + sulfate
-
-
-
?
3.1.6.2
estrone sulfate + H2O
estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase
716213
Homo sapiens
estrone + sulfate
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
2.8.2.4
Homo sapiens
enzyme activity is significantly higher in the endometrial carcinoma than in normal endometrial tissues
up
3.1.6.2
Homo sapiens
steroid sulfatase expression is upregulated in breast carcinomas
up
General Information
EC Number
General Information
Commentary
Organism
3.1.6.2
malfunction
steroid sulfatase/estrogen sulfotransferase status is associated with intratumoral estrogen level in the colon carcinoma, and steroid sulfatase-negative/estrogen sulfotransferase-positive colon carcinoma patients have longer survival. STS mRNA expression is higher in breast carcinoma tissues than that in normal breast tissues, and it is significantly associated with the breast carcinoma progression and poor clinical outcome of the patients
Homo sapiens
3.1.6.2
physiological function
activation of steroid sulfatase pathway due to increment in steroid sulfatase and/or decrement in estrogen sulfotransferase expressions plays important role in their estrogen-dependent growth
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.6.2
malfunction
steroid sulfatase/estrogen sulfotransferase status is associated with intratumoral estrogen level in the colon carcinoma, and steroid sulfatase-negative/estrogen sulfotransferase-positive colon carcinoma patients have longer survival. STS mRNA expression is higher in breast carcinoma tissues than that in normal breast tissues, and it is significantly associated with the breast carcinoma progression and poor clinical outcome of the patients
Homo sapiens
3.1.6.2
physiological function
activation of steroid sulfatase pathway due to increment in steroid sulfatase and/or decrement in estrogen sulfotransferase expressions plays important role in their estrogen-dependent growth
Homo sapiens
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.8.2.4
Homo sapiens
enzyme activity is significantly higher in the endometrial carcinoma than in normal endometrial tissues
up
3.1.6.2
Homo sapiens
steroid sulfatase expression is upregulated in breast carcinomas
up