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Literature summary extracted from

  • Suzuki, T.; Miki, Y.; Nakamura, Y.; Ito, K.; Sasano, H.
    Steroid sulfatase and estrogen sulfotransferase in human carcinomas (2011), Mol. Cell. Endocrinol., 340, 148-153.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.8.2.4 medicine enzyme immunoreactivity is inversely correlated with tumor size or lymph node status in the invasive breast carcinoma, and is also significantly associated with a decreased risk of recurrence or improved prognosis of the patients. Ovarian cancer patients with higher enzyme activity are significantly associated with shorter progression-free survival than those with lower enzyme activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.4 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone sulfate
-
 ?
3.1.6.2 estrone sulfate + H2O Homo sapiens estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase estrone + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
-
-
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 breast carcinoma cell
-
 Homo sapiens
-
2.8.2.4 colonic carcinoma cell
-
 Homo sapiens
-
2.8.2.4 endometrial carcinoma cell
-
 Homo sapiens
-
2.8.2.4 additional information the enzyme is not detected in non-neoplastic prostate tissues Homo sapiens
-
2.8.2.4 ovarian carcinoma cell
-
 Homo sapiens
-
2.8.2.4 prostate carcinoma cell
-
 Homo sapiens
-
3.1.6.2 breast carcinoma cell steroid sulfatase enzyme activity is detected in the great majority of breast carcinomas Homo sapiens
-
3.1.6.2 carcinoma cell
-
 Homo sapiens
-
3.1.6.2 colonic cancer cell
-
 Homo sapiens
-
3.1.6.2 endometrial cancer cell
-
 Homo sapiens
-
3.1.6.2 ovary cancer cell
-
 Homo sapiens
-
3.1.6.2 prostate gland cancer cell
-
 Homo sapiens
-
3.1.6.2 uterine endometrial carcinoma cell
-
 Homo sapiens
-
3.1.6.2 uterine endometrium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylylsulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone sulfate
-
 ?
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
3.1.6.2 estrone sulfate + H2O estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase Homo sapiens estrone + sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.4 EST
-
 Homo sapiens
2.8.2.4 estrogen sulfotransferase
-
 Homo sapiens
3.1.6.2 steroid sulfatase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.8.2.4 Homo sapiens enzyme activity is significantly higher in the endometrial carcinoma than in normal endometrial tissues up
3.1.6.2 Homo sapiens steroid sulfatase expression is upregulated in breast carcinomas up

General Information

EC Number General Information Comment Organism
3.1.6.2 malfunction steroid sulfatase/estrogen sulfotransferase status is associated with intratumoral estrogen level in the colon carcinoma, and steroid sulfatase-negative/estrogen sulfotransferase-positive colon carcinoma patients have longer survival. STS mRNA expression is higher in breast carcinoma tissues than that in normal breast tissues, and it is significantly associated with the breast carcinoma progression and poor clinical outcome of the patients Homo sapiens
3.1.6.2 physiological function activation of steroid sulfatase pathway due to increment in steroid sulfatase and/or decrement in estrogen sulfotransferase expressions plays important role in their estrogen-dependent growth Homo sapiens