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Literature summary extracted from

  • Ren, H.; Federico, L.; Huang, H.; Sunkara, M.; Drennan, T.; Frohman, M.; Smyth, S.; Morris, A.
    A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis (2010), Mol. Biol. Cell, 21, 3171-3181.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 D712E catalytically inactive mutant Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 cytosol
-
 Mus musculus 5829
-
3.1.3.4 membrane
-
 Mus musculus 16020
-
3.1.3.4 nucleus the transcriptional coactivator function of lipin1beta necessarily requires localization in the nucleus Mus musculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Mg2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O Mus musculus
-
 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 embryonic fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O
-
 Mus musculus 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipin1beta
-
 Mus musculus
3.1.3.4 phosphatidic acid phosphatase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.3.4 physiological function the lipin 1 polybasic motif is critical for lipin1beta function in phospholipid and neutral lipid metabolism. Lipin1beta also functions as transcriptional coactivator. Both the transcriptional and metabolic functions of lipin 1 are required for full complementation of the adipogenic differentiation of lipin-deficient MEF cells. Lipin1 is also an amplifier of PGC-1alpha, a nuclear coactivator of PPAR-alpha responsive gene transcription Mus musculus