BRENDA - Enzyme Database

A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis

Ren, H.; Federico, L.; Huang, H.; Sunkara, M.; Drennan, T.; Frohman, M.; Smyth, S.; Morris, A.; Mol. Biol. Cell 21, 3171-3181 (2010)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
D712E
catalytically inactive mutant
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Mus musculus
5829
-
3.1.3.4
membrane
-
Mus musculus
16020
-
3.1.3.4
nucleus
the transcriptional coactivator function of lipin1beta necessarily requires localization in the nucleus
Mus musculus
5634
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Mg2+
dependent on
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
phosphatidic acid + H2O
Mus musculus
-
1,2-diacyl-sn-glycerol + phosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
embryonic fibroblast
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
phosphatidic acid + H2O
-
716166
Mus musculus
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
D712E
catalytically inactive mutant
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
cytosol
-
Mus musculus
5829
-
3.1.3.4
membrane
-
Mus musculus
16020
-
3.1.3.4
nucleus
the transcriptional coactivator function of lipin1beta necessarily requires localization in the nucleus
Mus musculus
5634
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.3.4
Mg2+
dependent on
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
phosphatidic acid + H2O
Mus musculus
-
1,2-diacyl-sn-glycerol + phosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
embryonic fibroblast
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
phosphatidic acid + H2O
-
716166
Mus musculus
1,2-diacyl-sn-glycerol + phosphate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.1.3.4
physiological function
the lipin 1 polybasic motif is critical for lipin1beta function in phospholipid and neutral lipid metabolism. Lipin1beta also functions as transcriptional coactivator. Both the transcriptional and metabolic functions of lipin 1 are required for full complementation of the adipogenic differentiation of lipin-deficient MEF cells. Lipin1 is also an amplifier of PGC-1alpha, a nuclear coactivator of PPAR-alpha responsive gene transcription
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.3.4
physiological function
the lipin 1 polybasic motif is critical for lipin1beta function in phospholipid and neutral lipid metabolism. Lipin1beta also functions as transcriptional coactivator. Both the transcriptional and metabolic functions of lipin 1 are required for full complementation of the adipogenic differentiation of lipin-deficient MEF cells. Lipin1 is also an amplifier of PGC-1alpha, a nuclear coactivator of PPAR-alpha responsive gene transcription
Mus musculus