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Literature summary extracted from

  • Imae, R.; Inoue, T.; Kimura, M.; Kanamori, T.; Tomioka, N.H.; Kage-Nakadai, E.; Mitani, S.; Arai, H.
    Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol (2010), Mol. Biol. Cell, 21, 3114-3124.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.32 expression of IPLA-1 in HEK-293 cells Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.32 additional information acl-8 acl-9 acl-10 triple mutations cause misorientation of seam cell divisions similar to that observed in ipla-1 mutants Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.32 intracellular
-
 Caenorhabditis elegans 5622
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.32 Caenorhabditis elegans
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.32 recombinant IPLA-1 from HEK-293 cells Caenorhabditis elegans

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.32 additional information no activity with phosphatidylethanolamine and phosphatidic acid by intracellular phospholipase A1 Caenorhabditis elegans ?
-
 ?
3.1.1.32 phosphatidylcholine + H2O intracellular phospholipase A1 Caenorhabditis elegans lysophosphatidylcholine + fatty acid
-
 ?
3.1.1.32 phosphatidylinositol + H2O intracellular phospholipase A1 recognizes the sn-1 position of phosphatidylinositol as its substrate, recombinant IPLA-1 hydrolyzes a fatty acid attached to phosphatidylinositol Caenorhabditis elegans ?
-
 ?
3.1.1.32 phosphatidylserine + H2O intracellular phospholipase A1 Caenorhabditis elegans lysophosphatidylserine + fatty acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.32 intracellular phospholipase A1
-
 Caenorhabditis elegans
3.1.1.32 IPLA-1
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
3.1.1.32 malfunction Because orientation of seam cell division is randomized relative to the A-P axis in ipla-1 mutants, ipla-1 mutants exhibit aberrant orientation of seam cell divisions. Acl-8 acl-9 acl-10 triple mutations also cause misorientation of seam cell divisions similar to that observed in ipla-1 mutants Caenorhabditis elegans
3.1.1.32 metabolism intracellular phospholipase A1 and acyltransferase are involved in Caenorhabditis elegans stem cell divisions Caenorhabditis elegans
3.1.1.32 physiological function intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol Caenorhabditis elegans