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Literature summary extracted from

  • Wang, H.; Yang, B.; Hao, G.; Feng, Y.; Chen, H.; Feng, L.; Chen, Y.Q.; Zhao, J.; Zhang, H.; Wang, L.; Chen, W.
    Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus, Mortierella alpina (2011), Microbiology, 157, 3059-3070.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.12 expression in Escherichia coli Mortierella alpina

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.12 Co2+ complete inhibition Mortierella alpina
4.2.3.12 Cu2+ complete inhibition Mortierella alpina
4.2.3.12 Fe2+ slight inhibition Mortierella alpina
4.2.3.12 Mn2+ complete inhibition Mortierella alpina
4.2.3.12 additional information not inhibitory: dithiothreitol Mortierella alpina

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.12 0.164
-
 7,8-dihydroneopterin triphosphate pH 7.5, 25°C Mortierella alpina

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.12 Mg2+ 75% enhancement Mortierella alpina

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.3.12 21000
-
 * 21000, SDS-PAGE Mortierella alpina

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.12 Mortierella alpina G3FNL7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.3.12 recombinant protein Mortierella alpina

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.12 7,8-dihydroneopterin triphosphate
-
 Mortierella alpina 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.3.12 ? * 21000, SDS-PAGE Mortierella alpina

Synonyms

EC Number Synonyms Comment Organism
4.2.3.12 PTPS
-
 Mortierella alpina

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.3.12 37
-
-
 Mortierella alpina

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.2.3.12 5
-
 70% of maximum activity Mortierella alpina

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.3.12 7
-
-
 Mortierella alpina

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.2.3.12 4 10
-
 Mortierella alpina