EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.16 | calcitriol | calcitriol increases its own degradation in renal failure by increasing the enzymatic activity of 24-hydroxylase | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.15.16 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.15.16 | kidney | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.16 | 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Rattus norvegicus | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
1.14.15.16 | 25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Rattus norvegicus | 24R,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
1.14.15.16 | calcitriol + NADPH + H+ + O2 | - |
Rattus norvegicus | calcitetrol + NADP+ + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.15.16 | 24-hydroxylase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.16 | NADPH | - |
Rattus norvegicus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.14.15.16 | Rattus norvegicus | the enzymatic activity of intestinal 24-hydroxylase is significantly lower in renal failure rats compared to control sham operated rats | down |
1.14.15.16 | Rattus norvegicus | replacement of calcitriol (3 ng per day) significantly increases 24-hydroxylase activity by 17% in rats with renal failure, although the activity remains 15% lower than the controls | up |