EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.17.4.4 | D36V | naturally occuring mutation, warfarin resistant mutant | Homo sapiens |
1.17.4.4 | L128R | naturally occuring mutation, warfarin resistant mutant | Homo sapiens |
1.17.4.4 | R58G, | naturally occuring mutation, warfarin resistant mutant | Homo sapiens |
1.17.4.4 | V29L | naturally occuring mutation, warfarin resistant mutant | Homo sapiens |
1.17.4.4 | V45A | naturally occuring mutation, warfarin resistant mutant | Homo sapiens |
1.17.4.4 | V66M | naturally occuring mutation, warfarin resistant mutant | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.4 | warfarin | non-competitive inhibitor, displacement of the warfarin binding site away from the vitamin K binding site by at least one turn of the transmembrane helix. The fully extended phenyl group of S-warfarin may interact with the phenyl fragment of Tyr139 of VKOR in a stacking configuration. Binding of S-warfarin to VKOR in the presence of vitamin K could modify, i.e. reduce the rate of flip-flop of lipid membrane, ultimately leading to the decrease of the amount of the vitamin K hydroquinone form | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.4.4 | endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
1.17.4.4 | membrane | transmembrane protein with 5 transmembrane helices, membrane topology, overview | Homo sapiens | 16020 | - |
4.1.1.90 | endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Homo sapiens | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.4 | Homo sapiens | - |
- |
- |
4.1.1.90 | Homo sapiens | A7YA96 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Homo sapiens | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? | |
4.1.1.90 | L-glutamate + CO2 + O2 + vitamin K hydroquinone | - |
Homo sapiens | gamma-carboxy L-glutamate + vitamin K epoxide + H2O | - |
ir |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.1.1.90 | heterodimer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.4.4 | vitamin K epoxide reductase | - |
Homo sapiens |
1.17.4.4 | VKOR | - |
Homo sapiens |
1.17.4.4 | VKORC1 | - |
Homo sapiens |
4.1.1.90 | GGCX | - |
Homo sapiens |
4.1.1.90 | vitamin K carboxylase | - |
Homo sapiens |
4.1.1.90 | VKC | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.90 | vitamin K | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.17.4.4 | metabolism | vitamin K carboxylase converts vitamin K, in the vitamin K cycle, to an alkoxide-epoxide form which then reacts with CO2 and glutamate to generate gamma-carboxyglutamic acid. Subsequently, vitamin K epoxide reductase converts the alkoxide-epoxide to a hydroquinone form. By recycling vitamin K, the two integral-membrane proteins maintain vitamin K levels and sustain the blood coagulation cascade. Heterodimeric form of vitamin K carboxylase and vitamin K epoxide reductase may explain the efficient oxidation and reduction of vitamin K during the vitamin K cycle | Homo sapiens |
1.17.4.4 | additional information | possible heterodimeric form of vitamin K carboxylase and vitamin K epoxide reductase during the vitamin K cycle and co-localization on the lumenal side of endoplasmic reticulum membrane, molecular dynamics simulations and modeling, overview | Homo sapiens |
1.17.4.4 | physiological function | the enzyme is involved in the vitamin K cycle maintaining vitamin K levels and sustain the blood coagulation cascade | Homo sapiens |
4.1.1.90 | physiological function | VKC maintains vitamin K levels and sustains the blood coagulation cascade | Homo sapiens |