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Literature summary extracted from
- Mutational effects on the catalytic mechanism of cellobiohydrolase I from Trichoderma reesei (2011), J. Phys. Chem. B, 115, 4982-4989.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.2.1.176 | D214N | the mutant shows slightly reduced activity compared to the wild type enzyme | Trichoderma reesei |
| 3.2.1.176 | E212Q | the mutant loses most of its hydrolysis capability | Trichoderma reesei |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.176 | cellulose + H2O | Trichoderma reesei | the enzyme hydrolyzes the beta-1,4 linkages of a cellulose chain from its reducing end via a retaining mechanism liberating the product, which consists of roughly 63% beta-cellobiose and 37% alpha-cellobiose | alpha-cellobiose + beta-cellobiose | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.176 | Trichoderma reesei | P62694 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.176 | cellulose + H2O | the enzyme hydrolyzes the beta-1,4 linkages of a cellulose chain from its reducing end via a retaining mechanism liberating the product, which consists of roughly 63% beta-cellobiose and 37% alpha-cellobiose | Trichoderma reesei | alpha-cellobiose + beta-cellobiose | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.1.176 | Cel7A | - |
Trichoderma reesei |
| 3.2.1.176 | cellobiohydrolase I | - |
Trichoderma reesei |
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Release 2023.1 (January 2023)
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