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Literature summary extracted from

  • Lu, H.; Goren, A.C.; Zhan, C.G.
    Characterization of the structures of phosphodiesterase 10 binding with adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate by hybrid quantum mechanical/molecular mechanical calculations (2010), J. Phys. Chem. B, 114, 7022-7028.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.17 Mg2+ is coordinated to Asp564, two phosphate oxygen atoms, and three water molecules Homo sapiens
3.1.4.17 Zn2+ is coordinated to His529, His563, Asp564, Asp674, and two phosphate oxygen atoms Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.17 additional information Homo sapiens structure analysis of phosphodiesterase 10 binding with cAMP and cGMP by hybrid quantum mechanical/molecular mechanical calculations using cyrstal structures of the substrate-bound enzyme, detailed overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 adenosine 3',5'-cyclic phosphate + H2O
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 Homo sapiens adenosine 5'-phosphate
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 ?
3.1.4.17 guanosine 3',5'-cyclic phosphate + H2O
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 Homo sapiens guanosine 5'-phosphate
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 ?
3.1.4.17 additional information structure analysis of phosphodiesterase 10 binding with cAMP and cGMP by hybrid quantum mechanical/molecular mechanical calculations using cyrstal structures of the substrate-bound enzyme, detailed overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDE10
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 Homo sapiens
3.1.4.17 phosphodiesterase 10
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 Homo sapiens