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Literature summary extracted from

  • Lee, H.W.; Kim, Y.; Han, K.; Kim, H.; Kim, E.
    The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic (2010), J. Neurosci., 30, 5508-5518.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.64 additional information generation of an MTMR2 shRNA (sh-M1) that reduces exogenous MTMR2 expression in HEK 293T cells by about 80%, and endogenous MTMR2 expression in cultured hippocampal neurons by about 55%. MTMR2 knockdown in cultured hippocampal neurons leading to a marked reduction in the number of excitatory synapses, defined as PSD-95-positive dendritic spines, compared with neurons expressing empty shRNA vector Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.64 endosome predominantly Homo sapiens 5768
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3.1.3.64 synapse MTMR2 is localized to excitatory synapses of central neurons, localization in synaptic membrane, cytosol, and vesicles Homo sapiens 45202
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.64 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O Homo sapiens
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 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
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 ?
3.1.3.64 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O Homo sapiens
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 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?
3.1.3.64 additional information Homo sapiens PSD-95 interacts with MTMR2. MTMR2 is a 3-phosphatase specific for the phosphoinositides PI(3)P and PI(3,5)P2 ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.64 Homo sapiens
-
-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.64 hippocampus
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 Homo sapiens
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3.1.3.64 additional information PSD-95 interacts with and promotes spine localization of MTMR2 Homo sapiens
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3.1.3.64 neuron peripheral and central neurons, MTMR2 is localized to excitatory synapses of central neurons Homo sapiens
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3.1.3.64 Schwann cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.64 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?
3.1.3.64 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?
3.1.3.64 additional information PSD-95 interacts with MTMR2. MTMR2 is a 3-phosphatase specific for the phosphoinositides PI(3)P and PI(3,5)P2 Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.64 MTMR2
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 Homo sapiens
3.1.3.64 phosphoinositide 3-phosphatase
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 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.64 37
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.64 malfunction knockdown of MTMR2 reduces excitatory synapse number and suppresses synaptic transmission. Mutations in the MTMR2 gene in Schwann cells lead to a severe demyelinating peripheral neuropathy known as Charcot-Marie-Tooth disease type 4B1. Knockdown of MTMR2 in cultured neurons markedly reduces excitatory synapse density and function. It causes a marked reduction in the frequency, but not amplitude, of miniature EPSCs. This effect is rescued by wild-type MTMR2 but not by a mutant MTMR2 lacking PSD-95 binding or 3-phosphatase activity. MTMR2 knockdown leads to a decrease in the intensity of EEA1-positive early endosomes in dendrites but increases the intensity in the cell body region. Moreover, MTMR2 suppression promotes endocytosis, but not recycling, of the GluR2 subunit of AMPA receptors, which is an endosomal cargo. MTMR2 knockdown reduces spine density by suppressing spine maintenance, and not formation Homo sapiens
3.1.3.64 physiological function PSD-95 binding and phosphatase activities of MTMR2 are required for excitatory synapse maintenance. PSD-95-interacting MTMR2 contributes to the maintenance of excitatory synapses by inhibiting excessive endosome formation and destructive endosomal traffic to lysosomes. PSD-95 interacts with and promotes spine localization of MTMR2 Homo sapiens