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Literature summary extracted from

  • Keimpema, E.; Barabas, K.; Morozov, Y.M.; Tortoriello, G.; Torii, M.; Cameron, G.; Yanagawa, Y.; Watanabe, M.; Mackie, K.; Harkany, T.
    Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding (2010), J. Neurosci., 30, 13992-14007.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 brain MGL is expressed in central and peripheral axons of the fetal nervous system by embryonic day 12.5. MGL coexists with sn-1-diacylglycerol lipase alpha and CB1 cannabinoid receptors in corticofugal axons of pyramidal cells Mus musculus
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3.1.1.23 brain cortex MGL and CB1 cannabinoid receptors are coexpressed in corticofugal but not thalamocortical axons Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.23 2-arachidonoylglycerol + H2O
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 Mus musculus glycerol + arachidonic acid
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MGL
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 Mus musculus
3.1.1.23 monoacylglycerol lipase
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 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.23 malfunction MGL inactivation drives a CB1 cannabinoid receptor-dependent axonal growth response Mus musculus