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Literature summary extracted from
- Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis (2011), J. Nat. Prod., 74, 764-775.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.3.3.2 | synthesis | decreased production of campothecin on subculturing due to a cross-species biosynthetic pathway is where the endophyte Fusarium solani utilizes indigenous geraniol 10-hydroxylase, secologanin synthase, and tryptophan decarboxylase to biosynthesize precursors. Fusarium solani requires host Campotheca acuminata strictosidine synthase in order to form strictosidine. Biosynthetic genes of campothecin in the seventh subculture generation of the endophyte reveal random and unpredictable nonsynonymous mutations. These random base substitutions lead to dysfunction at the amino acid level. The controls, Top1 gene and rDNA, remained intact over subculturing | Camptotheca acuminata |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.3.3.2 | Camptotheca acuminata | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.3.3.2 | tryptamine + secologanin | - |
Camptotheca acuminata | 3-alpha(S)-strictosidine | - |
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