Literature summary extracted from

Bertrand, T.; Auge, F.; Houtmann, J.; Rak, A.; Vallee, F.; Mikol, V.; Berne, P.; Michot, N.; Cheuret, D.; Hoornaert, C.; Mathieu, M.
Structural basis for human monoglyceride lipase inhibition (2010), J. Mol. Biol., 396, 663-673.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.1.23	expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.1.1.23	apoenzyme alone or in complex with inhibitor SAR629, in 50 mM MES (pH 6.0) and 40% (v/v) 2-methyl-pentane-2,4-diol, at 4°C	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.23	JZL184	-	Homo sapiens
3.1.1.23	N-arachidonoylmaleimide	-	Homo sapiens
3.1.1.23	SAR629	substrate mimic	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.23	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.1.1.23	Ni-Sepharose column chromatography and Superdex 75 gel filtration	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.23	2-arachidonoylglycerol + H2O	-	Homo sapiens	glycerol + arachidonic acid	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.23	MGL	-	Homo sapiens
3.1.1.23	monoglyceride lipase	-	Homo sapiens

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Release 2023.1 (January 2023)