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Literature summary extracted from
- Sequence-dependent DNA flexibility mediates DNase I cleavage (2010), J. Mol. Biol., 395, 123-133.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.21.1 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.21.1 | commercial preparation | Bos taurus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.21.1 | additional information | - |
specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes. Productive DNA-DNase I interactions appear to be governed by one main DNA structural element: the minor groove width. Minor groove dimension results from various molecular mechanisms. For unbent DNA the local flexibility favors a wide minor groove. Since DNA flexibility is highly sequence dependent, base sequence influences the induced-fit transitions required to form DNA-DNase I complexes | Bos taurus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.21.1 | DNase I | - |
Bos taurus |
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Release 2023.1 (January 2023)
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