EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | Rattus norvegicus | - |
Prostaglandin I2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.4 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.4 | aortic adventitial fibroblast | - |
Rattus norvegicus | - |
5.3.99.4 | HAoAF cell | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin I2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.4 | PGI2 synthase | - |
Rattus norvegicus |
5.3.99.4 | PGIS | - |
Rattus norvegicus |
5.3.99.4 | Prostaglandin I2 synthase | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.4 | heme | - |
Rattus norvegicus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
5.3.99.4 | Rattus norvegicus | interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression | additional information |
5.3.99.4 | Rattus norvegicus | angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta | up |