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Literature summary extracted from

  • Tosi, J.; Davis, R.J.; Wang, N.K.; Naumann, M.; Lin, C.S.; Tsang, S.H.
    shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa (2011), J. Cell. Mol. Med., 15, 1778-1787.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.35 light light stimulates PDE6 activation, rapid reduction in cGMP, closure of Na+/Ca2+ channels and reduced Ca2+ influx Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.35 H620Q generation of Pde6bH620Q mice as mouse model, knockdown of guanylate cyclase and cGMP-gated Na+/Ca2+ channels, phenotype compared to control C57BL/6J mice, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 sildenafil
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Mus musculus
-
-
-
3.1.4.35 Mus musculus C57/BL6J
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 photoreceptor cell
-
 Mus musculus
-
3.1.4.35 retina
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.35 cGMP phosphodiesterase
-
 Mus musculus
3.1.4.35 PDE6
-
 Mus musculus
3.1.4.35 PDE6B
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.4.35 metabolism during rod phototransduction, cGMP and Ca2+ are regulated by PDE6, guanylate cyclase, and cGMP-gated Na+/Ca2+ channels. The level of cGMP is controlled by opposing activities of PDE6 and guanylate cyclase and, at sufficiently high levels, Na+/Ca2+ channels open to allow increased Ca2+ influx into the rod outer segment Mus musculus