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Literature summary extracted from

  • Gibbings, S.; Elkins, N.D.; Fitzgerald, H.; Tiao, J.; Weyman, M.E.; Shibao, G.; Fini, M.A.; Wright, R.M.
    Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha (2011), J. Biol. Chem., 286, 961-975.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.3.2 additional information XOR activity is specifically increased by inflammatory mononuclear phagocyte differentiation Rattus norvegicus
1.17.3.2 Th-1 cytokine increases XOR activity in inflammatory mononuclear phagocytes in vivo Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.3.2 ectopic overexpression of XOR cDNA and uric acid supplementation reducing SUMO-PPARgamma in inflammatory mononuclear phagocytes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid
-
 Rattus norvegicus
1.17.3.2 allopurinol
-
 Rattus norvegicus
1.17.3.2 oxypurinol
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Rattus norvegicus
-
 male
-
1.17.3.2 Rattus norvegicus Sprague-Dawley
-
 male
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 macrophage alveolar macrophages purified from the lung by lavage, and interstitial macrophages. Inflammatory cells express high levels of XOR activity, while in resident alveolar macrophage the enzyme content is extremely low prior to cytokine insufflation Rattus norvegicus
-
1.17.3.2 NR-8383 cell
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
1.17.3.2 xanthine oxidoreductase
-
 Rattus norvegicus
1.17.3.2 XOR
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.17.3.2 metabolism effects of enzyme inhibition in inflammatory macrophages, overview Rattus norvegicus
1.17.3.2 additional information xanthine oxidoreductase is implicated in many inflammatory diseases. Inhibition of XOR within the inflammatory mononuclear phagocytes, i.e. MNP, prevents neutrophil recruitment during adoptive transfer demonstrating the role of XOR in MNP-mediated neutrophil recruitment, role of XOR in the inflammatory state of MNP, overview. XOR activity is specifically increased by inflammatory mononuclear phagocyte differentiation. Inhibition of XOR reduces levels of CINC-1 secreted by inflammatory mononuclear phagocytes, and increases levels of SUMO-PPARgamma in the cell lines Rattus norvegicus