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Literature summary extracted from

  • Yukiura, H.; Hama, K.; Nakanaga, K.; Tanaka, M.; Asaoka, Y.; Okudaira, S.; Arima, N.; Inoue, A.; Hashimoto, T.; Arai, H.; Kawahara, A.; Nishina, H.; Aoki, J.
    Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish (2011), J. Biol. Chem., 286, 43972-43983.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 gene atx, DNA and amino acid sequence determination and analysis, recombinant expression in HEK-293 cells Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 additional information Danio rerio zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine ?
-
 ?
3.1.4.39 additional information Danio rerio AB zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Danio rerio
-
 gene atx
-
3.1.4.39 Danio rerio AB
-
 gene atx
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 additional information zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine Danio rerio ?
-
 ?
3.1.4.39 additional information zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine Danio rerio AB ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Danio rerio
3.1.4.39 autotaxin
-
 Danio rerio

General Information

EC Number General Information Comment Organism
3.1.4.39 malfunction knockdown of ATX in zebrafish embryos causes abnormal blood vessel formation. In ATX morphant embryos, the segmental arteries sprouted normally from the dorsal aorta but stalled in the mid-course resulting in aberrant vascular connection around the horizontal myoseptum Danio rerio
3.1.4.39 physiological function autotaxin is a multifunctional ecto-type phosphodiesterase that converts lysophospholipids such as lysophosphatidylcholine to lysophosphatidic acid by its lysophospholipase D activity. ATX has an essential role in embryonic blood vessel formation. Autotaxin is required for the development of intersegmental arteries in zebrafish Danio rerio