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Literature summary extracted from

  • Mathurin, K.; Gallant, M.A.; Germain, P.; Allard-Chamard, H.; Brisson, J.; Iorio-Morin, C.; de Brum Fernandes, A.; Caron, M.G.; Laporte, S.A.; Parent, J.L.
    An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production (2011), J. Biol. Chem., 286, 2696-2706.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.99.2 arrestin-3 arrestin-3 promotes prostaglandin D2 production by L-PGDS in vitro. Incubation of L-PGDS with arrestin-3 amino acids 56-100 enhances prostaglandin D2 production by 145% Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.2 expressed in Escherichia coli C41(DE3) cells Mus musculus
5.3.99.2 expressed in Escherichia coli C41(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.2 SeCl4
-
 Homo sapiens
5.3.99.2 SeCl4
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.2 cytoplasm
-
 Mus musculus 5737
-
5.3.99.2 cytoplasm
-
 Homo sapiens 5737
-
5.3.99.2 nucleus perinuclear L-type prostaglandin synthase/arrestin-3 co-localization is observed in prostaglandin D2-producing MG-63 cells Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.2 25000
-
 SDS-PAGE Mus musculus
5.3.99.2 25000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Homo sapiens
-
-
-
5.3.99.2 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.2 Ni-NTA agarose column chromatography and glutathione-Sepharose column chromatography Mus musculus
5.3.99.2 Ni-NTA agarose column chromatography and glutathione-Sepharose column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.2 MEF cell
-
 Mus musculus
-
5.3.99.2 MG-63 cell
-
 Homo sapiens
-
5.3.99.2 osteoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 Prostaglandin H2
-
 Mus musculus Prostaglandin D2
-
 ?
5.3.99.2 Prostaglandin H2
-
 Homo sapiens Prostaglandin D2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 L-PGDS also called beta-trace Mus musculus
5.3.99.2 L-PGDS also called beta-trace Homo sapiens
5.3.99.2 L-prostaglandin D synthase
-
 Mus musculus
5.3.99.2 L-prostaglandin D synthase
-
 Homo sapiens
5.3.99.2 L-type prostaglandin synthase
-
 Mus musculus
5.3.99.2 L-type prostaglandin synthase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.2 additional information L-PGDS is glutathione-independent Mus musculus
5.3.99.2 additional information L-PGDS is glutathione-independent Homo sapiens

General Information

EC Number General Information Comment Organism
5.3.99.2 malfunction co-localization of arrestin-3 with L-PGDS is drastically reduced in MG-63 cells when L-PGDS activity is inhibited Homo sapiens