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Literature summary extracted from

  • Novgorodov, S.A.; Wu, B.X.; Gudz, T.I.; Bielawski, J.; Ovchinnikova, T.V.; Hannun, Y.A.; Obeid, L.M.
    Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA (2011), J. Biol. Chem., 286, 25352-25362.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.20 4-chloromercuribenzoate inhibitor of acyl-CoA thioesterase 2 Rattus norvegicus
3.1.2.20 nordihydroguaiaretic acid inhibitor of acyl-CoA thioesterase 2 Rattus norvegicus
3.5.1.23 D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol inhibitor of alkaline ceramidase Mus musculus
3.5.1.23 D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol inhibitor of alkaline ceramidase Rattus norvegicus
3.5.1.23 N-oleoylethanolamine inhibitor of acid ceramidase Mus musculus
3.5.1.23 N-oleoylethanolamine inhibitor of acid ceramidase Rattus norvegicus
3.5.1.23 urea-hexanoyl-ceramide
-
 Mus musculus
3.5.1.23 urea-hexanoyl-ceramide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.20 mitochondrion
-
 Rattus norvegicus 5739
-
3.5.1.23 mitochondrion
-
 Mus musculus 5739
-
3.5.1.23 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.23 ceramide + H2O Mus musculus
-
 sphingosine + fatty acid
-
 ?
3.5.1.23 ceramide + H2O Rattus norvegicus
-
 sphingosine + fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.20 Rattus norvegicus
-
-
-
3.5.1.23 Mus musculus
-
-
-
3.5.1.23 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.20 liver
-
 Rattus norvegicus
-
3.5.1.23 liver
-
 Mus musculus
-
3.5.1.23 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.20 palmitoyl-CoA + H2O
-
 Rattus norvegicus palmitate + CoA
-
 ?
3.5.1.23 ceramide + H2O
-
 Mus musculus sphingosine + fatty acid
-
 ?
3.5.1.23 ceramide + H2O
-
 Rattus norvegicus sphingosine + fatty acid
-
 ?
3.5.1.23 D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O
-
 Mus musculus 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine
-
 r
3.5.1.23 D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O
-
 Rattus norvegicus 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.1.2.20 acyl-CoA thioesterase
-
 Rattus norvegicus
3.1.2.20 palmitoyl-CoA hydrolase
-
 Rattus norvegicus
3.5.1.23 nCDase
-
 Mus musculus
3.5.1.23 nCDase
-
 Rattus norvegicus
3.5.1.23 neutral ceramidase
-
 Mus musculus
3.5.1.23 neutral ceramidase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.5.1.23 physiological function neutral ceramidase is a key participant of ceramide formation in liver mitochondria. The reverse activity of neutral ceramidase contributes to sphingolipid homeostasis in this organelle in vivo. The enzyme contributes to the overall ceramide profile of liver mitochondria at basal conditions in vivo Mus musculus
3.5.1.23 physiological function neutral ceramidase is a key participant of ceramide formation in liver mitochondria. The reverse activity of neutral ceramidase contributes to sphingolipid homeostasis in this organelle in vivo. The enzyme contributes to the overall ceramide profile of liver mitochondria at basal conditions in vivo Rattus norvegicus