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Literature summary extracted from

  • Jones, C.G.; Moniodis, J.; Zulak, K.G.; Scaffidi, A.; Plummer, J.A.; Ghisalberti, E.L.; Barbour, E.L.; Bohlmann, J.
    Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases (2011), J. Biol. Chem., 286, 17445-17454.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.81 expression in Escherichia coli Santalum album
4.2.3.81 expression in Escherichia coli Santalum austrocaledonicum
4.2.3.81 expression in Escherichia coli Santalum spicatum
4.2.3.81 heterologous expression of a His6-tagged protein in Escherichia coli Santalum album
4.2.3.81 heterologous expression of a His6-tagged protein in Escherichia coli Santalum austrocaledonicum
4.2.3.81 heterologous expression of a His6-tagged protein in Escherichia coli Santalum spicatum
4.2.3.82 expression in Escherichia coli Santalum album
4.2.3.82 expression in Escherichia coli Santalum austrocaledonicum
4.2.3.82 expression in Escherichia coli Santalum spicatum
4.2.3.82 heterologous expression of a His6-tagged protein in Escherichia coli Santalum album
4.2.3.82 heterologous expression of a His6-tagged protein in Escherichia coli Santalum austrocaledonicum
4.2.3.82 heterologous expression of a His6-tagged protein in Escherichia coli Santalum spicatum
4.2.3.83 expression in Escherichia coli Santalum album
4.2.3.83 expression in Escherichia coli Santalum austrocaledonicum
4.2.3.83 expression in Escherichia coli Santalum spicatum
4.2.3.83 heterologous expression of a His6-tagged protein in Escherichia coli Santalum album
4.2.3.83 heterologous expression of a His6-tagged protein in Escherichia coli Santalum austrocaledonicum
4.2.3.83 heterologous expression of a His6-tagged protein in Escherichia coli Santalum spicatum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.81 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum album
4.2.3.81 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum austrocaledonicum
4.2.3.81 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum spicatum
4.2.3.81 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.81 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.81 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.82 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum album
4.2.3.82 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum austrocaledonicum
4.2.3.82 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum spicatum
4.2.3.82 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.82 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.82 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.83 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum album
4.2.3.83 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum austrocaledonicum
4.2.3.83 0.0014
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum spicatum
4.2.3.83 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.83 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.83 0.0014
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.81 Mg2+ required Santalum album
4.2.3.81 Mg2+ required Santalum austrocaledonicum
4.2.3.81 Mg2+ required Santalum spicatum
4.2.3.81 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album
4.2.3.81 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.81 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.81 Mn2+ incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.81 Mn2+ incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.81 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album
4.2.3.81 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.81 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.82 Mg2+ required Santalum album
4.2.3.82 Mg2+ required Santalum austrocaledonicum
4.2.3.82 Mg2+ required Santalum spicatum
4.2.3.82 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album
4.2.3.82 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.82 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.82 Mn2+ incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.82 Mn2+ incubation in presence of Mn2+ yields mainly exo-alpha-bergamotene Santalum spicatum
4.2.3.82 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album
4.2.3.82 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.82 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.83 Mg2+ required Santalum album
4.2.3.83 Mg2+ required Santalum austrocaledonicum
4.2.3.83 Mg2+ required Santalum spicatum
4.2.3.83 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album
4.2.3.83 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.83 Mg2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.83 Mn2+ incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.83 Mn2+ incubation in presence of Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum
4.2.3.83 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album
4.2.3.83 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum
4.2.3.83 Mn2+ when incubated in the presence of 10 mM Mg2+ the enzyme converts (E,E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.3.81 65163
-
 x * 65163, calculated from sequence Santalum album
4.2.3.81 65268
-
 x * 65268, calculated from sequence Santalum austrocaledonicum
4.2.3.81 65407
-
 x * 65407, calculated from sequence Santalum spicatum
4.2.3.81 66000
-
-
 Santalum album
4.2.3.82 65163
-
 x * 65163, calculated from sequence Santalum album
4.2.3.82 65268
-
 x * 65268, calculated from sequence Santalum austrocaledonicum
4.2.3.82 65407
-
 x * 65407, calculated from sequence Santalum spicatum
4.2.3.82 66000
-
-
 Santalum album
4.2.3.83 65163
-
 x * 65163, calculated from sequence Santalum album
4.2.3.83 65268
-
 x * 65268, calculated from sequence Santalum austrocaledonicum
4.2.3.83 65407
-
 x * 65407, calculated from sequence Santalum spicatum
4.2.3.83 66000
-
-
 Santalum album

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.81 (2E,6E)-farnesyl diphosphate Santalum album
-
 (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate Santalum austrocaledonicum
-
 (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate Santalum spicatum
-
 (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate Santalum spicatum
-
 exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 (2E,6E)-farnesyl diphosphate Santalum album
-
 exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 (2E,6E)-farnesyl diphosphate Santalum austrocaledonicum
-
 exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 additional information Santalum album Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (6E,6E)-farnesyl diphosphate resembles the authentic essential oil of Santalum album more closely than that of the (6Z,6Z)-farnesyl diphosphate incubations ?
-
 ?
4.2.3.81 additional information Santalum austrocaledonicum Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranxyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene ?
-
 ?
4.2.3.81 additional information Santalum spicatum Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene ?
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate Santalum album
-
 (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate Santalum austrocaledonicum
-
 (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate Santalum spicatum
-
 (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate Santalum austrocaledonicum
-
 alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.82 (2E,6E)-farnesyl diphosphate Santalum spicatum
-
 alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.82 (2E,6E)-farnesyl diphosphate Santalum album
-
 alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.82 additional information Santalum album Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations ?
-
 ?
4.2.3.82 additional information Santalum austrocaledonicum Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene ?
-
 ?
4.2.3.82 additional information Santalum spicatum Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene ?
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate Santalum album
-
 (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate Santalum austrocaledonicum
-
 (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate Santalum spicatum
-
 (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate Santalum austrocaledonicum
-
 alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 (2E,6E)-farnesyl diphosphate Santalum album
-
 beta-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 (2E,6E)-farnesyl diphosphate Santalum spicatum
-
 beta-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 additional information Santalum album Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranxyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations ?
-
 ?
4.2.3.83 additional information Santalum austrocaledonicum Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene ?
-
 ?
4.2.3.83 additional information Santalum spicatum Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.81 Santalum album E3W202
-
-
4.2.3.81 Santalum austrocaledonicum E3W203
-
-
4.2.3.81 Santalum spicatum E3W204
-
-
4.2.3.82 Santalum album E3W202
-
-
4.2.3.82 Santalum austrocaledonicum E3W203
-
-
4.2.3.82 Santalum spicatum E3W204
-
-
4.2.3.83 Santalum album E3W202
-
-
4.2.3.83 Santalum austrocaledonicum E3W203
-
-
4.2.3.83 Santalum spicatum E3W204
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.81 xylem
-
 Santalum album
-
4.2.3.81 xylem
-
 Santalum austrocaledonicum
-
4.2.3.81 xylem
-
 Santalum spicatum
-
4.2.3.82 xylem
-
 Santalum album
-
4.2.3.82 xylem
-
 Santalum austrocaledonicum
-
4.2.3.82 xylem
-
 Santalum spicatum
-
4.2.3.83 xylem
-
 Santalum album
-
4.2.3.83 xylem
-
 Santalum austrocaledonicum
-
4.2.3.83 xylem
-
 Santalum spicatum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum album (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum (-)-exo-alpha-bergamotene + diphosphate
-
 ?
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum album exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum exo-alpha-bergamotene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.81 additional information Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (6E,6E)-farnesyl diphosphate resembles the authentic essential oil of Santalum album more closely than that of the (6Z,6Z)-farnesyl diphosphate incubations Santalum album ?
-
 ?
4.2.3.81 additional information Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranxyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum austrocaledonicum ?
-
 ?
4.2.3.81 additional information Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum spicatum ?
-
 ?
4.2.3.81 additional information Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum album ?
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate
-
 Santalum album (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2Z,6Z)-farnesyl diphosphate into alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene and beta-santalene Santalum album (+)-alpha-santalene + diphosphate
-
 ?
4.2.3.82 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.82 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, alpha-exo-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.82 (2E,6E)-farnesyl diphosphate
-
 Santalum album alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.82 additional information Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations Santalum album ?
-
 ?
4.2.3.82 additional information Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum austrocaledonicum ?
-
 ?
4.2.3.82 additional information Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum spicatum ?
-
 ?
4.2.3.82 additional information Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum album ?
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum album (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum album (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum austrocaledonicum (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2E,6E)-farnesyl diphosphate into alpha-santalene, beta-santalene and epi-beta-santalene,alpha-exo-bergamotene, as well as traces of alpha-farnesene and beta-farnesene. Incubations with Mn2+ yields mainly alpha-exo-bergamotene Santalum spicatum (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum alpha-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum album beta-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum austrocaledonicum beta-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 (2E,6E)-farnesyl diphosphate
-
 Santalum spicatum beta-santalene + diphosphate products are alpha-santalene, beta-, and epi-beta-santalene, exo-alpha-bergamotene, as well as traces of alpha- and beta-farnesene ?
4.2.3.83 (2Z,6Z)-farnesyl diphosphate when incubated in the presence of 10 mM Mg2+ the enzyme converts (2Z,6Z)-farnesyl diphosphate into alpha-endo-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene and beta-santalene Santalum album (-)-beta-santalene + diphosphate
-
 ?
4.2.3.83 additional information Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranxyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene. The product profile resulting from incubations of SaSSy with (E,E)-FPP resembles the authentic essential oil of Santalum album more closely than that of the (Z,Z)-FPP incubations Santalum album ?
-
 ?
4.2.3.83 additional information Santalum austrocaledonicum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum austrocaledonicum ?
-
 ?
4.2.3.83 additional information Santalum spicatum Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum spicatum ?
-
 ?
4.2.3.83 additional information Santalum album Ssy also accepts (2Z,6Z)-farnesyl diphosphate as substrate, producing a mixture of endo-alpha-bergamotene, alpha-santalene, (Z)-beta-farnesene, epi-beta-santalene, and beta-santalene. With substrate geranxyl diphosphate, products are linalool, geraniol, and terpineol along with traces of alpha-pinene and camphene Santalum album ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.3.81 ? x * 65163, calculated from sequence Santalum album
4.2.3.81 ? x * 65268, calculated from sequence Santalum austrocaledonicum
4.2.3.81 ? x * 65407, calculated from sequence Santalum spicatum
4.2.3.81 ? x * 66000, SDS-PAGE of recombinant His-tagged protein Santalum album
4.2.3.82 ? x * 65163, calculated from sequence Santalum album
4.2.3.82 ? x * 65268, calculated from sequence Santalum austrocaledonicum
4.2.3.82 ? x * 65407, calculated from sequence Santalum spicatum
4.2.3.82 ? x * 66000, SDS-PAGE of recombinant His-tagged protein Santalum album
4.2.3.83 ? x * 65163, calculated from sequence Santalum album
4.2.3.83 ? x * 65268, calculated from sequence Santalum austrocaledonicum
4.2.3.83 ? x * 65407, calculated from sequence Santalum spicatum
4.2.3.83 ? x * 66000, SDS-PAGE of recombinant His-tagged protein Santalum album

Synonyms

EC Number Synonyms Comment Organism
4.2.3.81 SaSSy
-
 Santalum album
4.2.3.81 SspiSy
-
 Santalum spicatum
4.2.3.81 SSy
-
 Santalum album
4.2.3.81 SSy
-
 Santalum austrocaledonicum
4.2.3.81 SSy
-
 Santalum spicatum
4.2.3.81 SuSSy
-
 Santalum austrocaledonicum
4.2.3.82 SaSSy
-
 Santalum album
4.2.3.82 SspiSy
-
 Santalum spicatum
4.2.3.82 SSy
-
 Santalum album
4.2.3.82 SSy
-
 Santalum austrocaledonicum
4.2.3.82 SSy
-
 Santalum spicatum
4.2.3.82 SuSSy
-
 Santalum austrocaledonicum
4.2.3.83 SaSSy
-
 Santalum album
4.2.3.83 SspiSy
-
 Santalum spicatum
4.2.3.83 SSy
-
 Santalum album
4.2.3.83 SSy
-
 Santalum austrocaledonicum
4.2.3.83 SSy
-
 Santalum spicatum
4.2.3.83 SuSSy
-
 Santalum austrocaledonicum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.3.81 25
-
 assay at Santalum album
4.2.3.81 25
-
 assay at Santalum austrocaledonicum
4.2.3.81 25
-
 assay at Santalum spicatum
4.2.3.82 25
-
 assay at Santalum album
4.2.3.82 25
-
 assay at Santalum austrocaledonicum
4.2.3.82 25
-
 assay at Santalum spicatum
4.2.3.83 25
-
 assay at Santalum album
4.2.3.83 25
-
 assay at Santalum austrocaledonicum
4.2.3.83 25
-
 assay at Santalum spicatum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.3.81 0.34
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.81 0.34
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum album
4.2.3.81 0.91
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.81 0.91
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum austrocaledonicum
4.2.3.81 2.6
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.81 2.6
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum spicatum
4.2.3.82 0.34
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.82 0.34
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum album
4.2.3.82 0.91
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.82 0.91
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum austrocaledonicum
4.2.3.82 2.6
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.82 2.6
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum spicatum
4.2.3.83 0.34
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.83 0.34
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum album
4.2.3.83 0.91
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.83 0.91
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum austrocaledonicum
4.2.3.83 2.6
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.83 2.6
-
 (2E,6E)-farnesyl diphosphate 30°C, pH 8.0 Santalum spicatum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.3.81 7.4
-
 assay at Santalum album
4.2.3.81 7.4
-
 assay at Santalum austrocaledonicum
4.2.3.81 7.4
-
 assay at Santalum spicatum
4.2.3.82 7.4
-
 assay at Santalum album
4.2.3.82 7.4
-
 assay at Santalum austrocaledonicum
4.2.3.82 7.4
-
 assay at Santalum spicatum
4.2.3.83 7.4
-
 assay at Santalum album
4.2.3.83 7.4
-
 assay at Santalum austrocaledonicum
4.2.3.83 7.4
-
 assay at Santalum spicatum

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.3.81 242.9
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.81 650
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.81 1857
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.82 242.9
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.82 650
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.82 1857
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum
4.2.3.83 242.9
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum album
4.2.3.83 650
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum austrocaledonicum
4.2.3.83 1857
-
 (2E,6E)-farnesyl diphosphate pH 7.4, 25°C Santalum spicatum