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Literature summary extracted from

  • Nakamura, T.; Meshitsuka, S.; Kitagawa, S.; Abe, N.; Yamada, J.; Ishino, T.; Nakano, H.; Tsuzuki, T.; Doi, T.; Kobayashi, Y.; Fujii, S.; Sekiguchi, M.; Yamagata, Y.
    Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base (2010), J. Biol. Chem., 285, 444-452.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.55 expression in Escherichia coli Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.55 the crystal structures of MutT in the apo and holo forms and in the binary and ternary forms complexed with the product 8-oxo-dGMP and 8-oxo-dGMP plus Mn2+, respectively, are determined Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.55 8-oxo-dGTP + H2O Escherichia coli the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA 8-oxo-dGMP + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.55 Escherichia coli P08337
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-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.55
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.55 8-oxo-dGTP + H2O the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA Escherichia coli 8-oxo-dGMP + diphosphate
-
?
3.6.1.55 8-oxo-dGTP + H2O MutT exhibits high substrate specificity for 8-oxoguanine nucleotides by the ligand-induced conformational change Escherichia coli 8-oxo-dGMP + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.55 MutT
-
Escherichia coli