EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.3.4 | His-tagged version | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
4.1.3.4 | vapor diffusion method | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.1.3.4 | K48N | inherited mutation | Homo sapiens |
4.1.3.4 | K48Q | mimics Lys acetylation | Homo sapiens |
4.1.3.4 | R41M | catalytically deficient | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.3.4 | 3-hydroxyglutaryl-CoA | competitive inhibitor | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.3.4 | 0.0134 | - |
3-hydroxy-3-methylglutaryl-CoA | K48Q mutant protein, pH not specified in the publication, 30°C | Homo sapiens | |
4.1.3.4 | 0.0209 | - |
3-hydroxy-3-methylglutaryl-CoA | K48N mutant protein, pH not specified in the publication, 30°C | Homo sapiens | |
4.1.3.4 | 0.0265 | - |
3-hydroxy-3-methylglutaryl-CoA | wild type protein, pH not specified in the publication, 30°C | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.1.3.4 | Mg2+ | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.3.4 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.3.4 | - |
Homo sapiens |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.1.3.4 | 87.8 | - |
K48N mutant protein, pH not specified in the publication, 30°C | Homo sapiens |
4.1.3.4 | 100.3 | - |
K48Q mutant protein, pH not specified in the publication, 30°C | Homo sapiens |
4.1.3.4 | 136 | - |
wild type protein, pH not specified in the publication, 30°C | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.3.4 | 3-hydroxy-3-methylglutaryl-CoA | - |
Homo sapiens | acetoacetate + acetyl-CoA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.3.4 | 3-Hydroxy-3-methylglutaryl-CoA lyase | - |
Homo sapiens |