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Literature summary extracted from

  • Moiseyev, G.; Takahashi, Y.; Chen, Y.; Gentleman, S.; Redmond, T.M.; Crouch, R.K.; Ma, J.X.
    RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle (2006), J. Biol. Chem., 281, 2835-2840.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.64 expressed in 293A-LRAT cells Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.64 1,10-phenanthroline dose-dependent inhibition Bos taurus
3.1.1.64 2,2'-bipyridine dose-dependent inhibition Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.64 microsome
-
Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.64 Fe2+ Fe2+ is essential for the isomerohydrolase activity Bos taurus
3.1.1.64 additional information not affected by Fe(III) citrate, Fe3+, Cu2+, Zn2+, or Mg2+ Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.64 DEAE-Sepharose column chromatography Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 retinal pigment epithelium
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 all-trans-retinyl ester + H2O
-
Bos taurus 11-cis-retinol + a fatty acid
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 Rpe65
-
Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.64 0.2
-
in 10 mM 1,3-bis[tris(hydroxymethyl)methylamino]propane, pH 8.0, 100 mM NaCl, at 37°C Bos taurus 1,10-phenanthroline
3.1.1.64 0.5
-
in 10 mM 1,3-bis[tris(hydroxymethyl)methylamino]propane, pH 8.0, 100 mM NaCl, at 37°C Bos taurus 2,2'-bipyridine