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Literature summary extracted from

  • Chen, P.; Lee, T.D.; Fong, H.K.
    Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal G protein-coupled receptor opsin (2001), J. Biol. Chem., 276, 21098-21104.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.315 microsome
-
Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.315 32000
-
x * 32000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.315 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+ Bos taurus
-
11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
?
1.1.1.315 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+ Bos taurus
-
11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+
-
?
1.1.1.315 additional information Bos taurus cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.315 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.315 enzyme copurifies with retinal G protein coupled receptor from microsomes Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.315 retina
-
Bos taurus
-
1.1.1.315 retinal pigment epithelium
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.315 11-cis-retinol-[cellular retinaldehyde binding protein] + NAD+
-
Bos taurus 11-cis-retinal-[cellular retinaldehyde binding protein] + NADH + H+
-
?
1.1.1.315 11-cis-retinol-[cellular retinaldehyde binding protein] + NADP+
-
Bos taurus 11-cis-retinal-[cellular retinaldehyde binding protein] + NADPH + H+
-
?
1.1.1.315 additional information cRDH does not react with endogenous all-trans-retinal bound to retinal G protein-coupled receptor RGR but reacts specifically with 11-cis-retinal that is generated by photoisomerization after irradiation of RGR. The reduction of 11-cis-retinal to 11-cis-retinol by cRDH enhances the net photoisomerization of all-trans-retinal bound to RGR Bos taurus ?
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.315 ? x * 32000, SDS-PAGE Bos taurus
1.1.1.315 More enzyme copurifies with retinal G protein coupled receptor from microsomes Bos taurus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.315 cRDH
-
Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.315 NAD+ NAD+ is preferred over NADP+ Bos taurus
1.1.1.315 NADP+ NAD+ is preferred over NADP+ Bos taurus

General Information

EC Number General Information Comment Organism
1.1.1.315 physiological function cRDH is involved in the processing of 11-cis-retinal after irradiation of retinal G protein-coupled receptor RGR opsin and plays a role in the visual cycle Bos taurus