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Literature summary extracted from

  • Nutter, L.M.; Ngo, E.O.; Fisher, G.R.; Gutierrez, P.L.
    DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase (1992), J. Biol. Chem., 267, 2474-2479.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.6.5.5 medicine QAO does not possess a protective role in menadione-induced free radical production and DNA damage in human cancer cells. Under aerobic conditions, menadiol produced by QAR is readily oxidized to menadione by two 1-electron steps producing the semiquinone and the parent quinone with concomitant production of superoxide anion, which leads to generation of hydroxyl radicals Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.5 dicoumarol presence of dicoumarol decreases the production of hydroxyl radical and attenuates DNA strand-breaks in MCF-7 cells treated with menadione Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.5 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.5 menadione + NADPH + H+
-
 Homo sapiens menadiol + NADP+ under aerobic conditions, menadiol is readily oxidized to menadione by two 1-electron steps producing the semiquinone and the parent quinone with concomitant production of superoxide anion, which leads to generation of hydroxyl radicals ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.5 NADPH quinone acceptor oxidoreductase
-
 Homo sapiens
1.6.5.5 QAO
-
 Homo sapiens