Literature summary extracted from
Srivastava, M.; Mallard, C.; Barke, T.; Hancock, L.E.; Self, W.T.
A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production (2011), J. Bacteriol., 193, 1643-1652.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.17.1.4 |
additional information |
isolation of selD and xdh in-frame deletion mutants with null phenotype for biofilm formation. The wild-type strain produces significant levels of superoxide, whereas the selD and xdh mutants do not exhibit superoxide production, overview |
Enterococcus faecalis |
Metals/Ions
EC Number |
Metals/Ions |
Comment |
Organism |
Structure |
---|
1.17.1.4 |
selenium |
dependent on, selenium is required in a labile form |
Enterococcus faecalis |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.17.1.4 |
Enterococcus faecalis |
- |
gene xdh |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.17.1.4 |
XDH |
- |
Enterococcus faecalis |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.17.1.4 |
metabolism |
xanthine dehydrogenase activity correlates with the presence of this labile selenoprotein complex and is absent in a selD, encoding selenophosphate synthetase, or an xdh mutant, overview. Peroxide levels are not increased in either the selD or the xdh mutant upon addition of selenite |
Enterococcus faecalis |
1.17.1.4 |
additional information |
biofilm formation is stimulated in the presence of uric acid, Se, and Mo and inhibited by auranofin or tungstate |
Enterococcus faecalis |
1.17.1.4 |
physiological function |
xanthine dehydrogenase is necessary for extracellular superoxide and hydrogen peroxide production by the organism. The selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production |
Enterococcus faecalis |