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Literature summary extracted from

  • McIntyre, N.R.; Lowe, E.W.; Belof, J.L.; Ivkovic, M.; Shafer, J.; Space, B.; Merkler, D.J.
    Evidence for substrate preorganization in the peptidylglycine alpha-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling (2010), J. Am. Chem. Soc., 132, 16393-16402.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.17.3
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.3 0.1
-
 O2 substrate N-decanoylglycine, pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.11
-
 N-decanoylglycine pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.11
-
 O2 substrate N-octanoylglycine, pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.15
-
 O2 substrate N-hexanoylglycine, pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.17
-
 O2 substrate N-butyrylglycine, pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.2
-
 N-octanoylglycine pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.21
-
 O2 substrate N-propionylglycine, pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.23
-
 O2 substrate N-acetylglycine, pH 6.0, 37°C Rattus norvegicus
1.14.17.3 0.58
-
 N-hexanoylglycine pH 6.0, 37°C Rattus norvegicus
1.14.17.3 2.3
-
 N-butyrylglycine pH 6.0, 37°C Rattus norvegicus
1.14.17.3 2.4
-
 N-propionylglycine pH 6.0, 37°C Rattus norvegicus
1.14.17.3 18
-
 N-acetylglycine pH 6.0, 37°C Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.3 Cu2+ peptidylglycine alpha-hydroxylating monooxygenase Rattus norvegicus
1.14.17.3 Zn2+ peptigylamidoglycolate lyase Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.17.3
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.3 medullary thyroid carcinoma cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.3 N-acetylglycine + 2 ascorbate + O2
-
 Rattus norvegicus N-acetyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
 ?
1.14.17.3 N-butyrylglycine + 2 ascorbate + O2
-
 Rattus norvegicus N-butyryl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
 ?
1.14.17.3 N-decanoylglycine + 2 ascorbate + O2
-
 Rattus norvegicus N-decanoyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
 ?
1.14.17.3 N-hexanoylglycine + 2 ascorbate + O2
-
 Rattus norvegicus N-hexanoyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
 ?
1.14.17.3 N-octanoylglycine + 2 ascorbate + O2
-
 Rattus norvegicus N-octanoyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
 ?
1.14.17.3 N-propionylglycine + 2 ascorbate + O2
-
 Rattus norvegicus N-propionyl-2-hydroxyglycine + 2 semidehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + 2 ascorbate + O2
-
 Rattus norvegicus peptidyl(2-hydroxyglycine) + 2 semidehydroascorbate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.3 peptidylglycine alpha-amidating monooxygenase bifunctional enzyme: peptidylglycine alpha-hydroxylating monooxygenase and peptigylamidoglycolate lyase Rattus norvegicus